α-glucosidase inhibitors isolated from L.

Journal: Natural product research
PMID: 29281898

Abstract

The aim of the study was to isolate digestive enzymes inhibitors from through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicularin as digestive enzymes inhibitors whose IC values as compared to acarbose (351.02 ± 1.46 μg mL) were found to be as 91.08 ± 1.54, 75.16 ± 0.92 and 481.7 ± 0.703 μg mL, respectively. In conclusion, could be a good and safe source of digestive enzymes inhibitors for the management of diabetes in future.

Authors

  • S T Tasnuva
    a Faculty of Pharmacy , International Islamic University Malaysia, Kuantan Campus , Kuantan , Malaysia.
  • U A Qamar
    a Faculty of Pharmacy , International Islamic University Malaysia, Kuantan Campus , Kuantan , Malaysia.
  • Kashif Ghafoor
    Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia. Electronic address: kashif_ft@hotmail.com.
  • F Sahena
    c Faculty of Science , International Islamic University Malaysia (IIUM), Kuantan Campus , Kuantan , Malaysia.
  • M H A Jahurul
    d Faculty of Food Science and Nutrition , Universiti Malaysia Sabah , Kota Kinabalu , Malaysia.
  • A H Rukshana
    e Faculty of Basic Medical and Pharmaceutical Sciences , University of Science and Technology Chittagong , Chittagong , Bangladesh.
  • M J Juliana
    a Faculty of Pharmacy , International Islamic University Malaysia, Kuantan Campus , Kuantan , Malaysia.
  • Fahad Y Al-Juhaimi
    b Department of Food Science and Nutrition , King Saud University , Riyadh , Saudi Arabia.
  • L Jalifah
    f Faculty of Science and Technology , University Kebangsaan Malaysia , Bangi , Malaysia.
  • K C A Jalal
    c Faculty of Science , International Islamic University Malaysia (IIUM), Kuantan Campus , Kuantan , Malaysia.
  • Md Eaqub Ali
    g Nanotechnology and Catalysis Research Centre (NanoCat) , University of Malaya , Kuala Lumpur , Malaysia.
  • I S M Zaidul
    a Faculty of Pharmacy , International Islamic University Malaysia, Kuantan Campus , Kuantan , Malaysia.

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