AIMC Topic: alpha-Glucosidases
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Chemical Properties-Based Deep Learning Models for Recommending Rational Daily Diet Combinations to Diabetics Through Large-Scale Virtual Screening of α-Glucosidase Dietary-Derived Inhibitors and Verified In Vitro.
Journal of agricultural and food chemistry
Jun 5, 2025
The lack of suitable chemical research methodologies has hindered the discovery of rational daily diet combinations from large-scale dietary-derived compounds. Three deep learning models based on chemical properties for α-glucosidase inhibitors (AGIs...
Design, synthesis, and evaluation of triazolo[1,5-a]pyridines as novel and potent α‑glucosidase inhibitors.
Scientific reports
May 22, 2025
α-Glucosidase is a key enzyme responsible for controlling the blood glucose, making a pivotal target in the treatment of type 2 diabetes mellitus. Present work introducestriazolo[1,5-a]pyridine as a novel, potent scaffold for α-glucosidase inhibition...
Highlights of Precision Medicine, Genetics, Epigenetics and Artificial Intelligence in Pompe Disease.
International journal of molecular sciences
Jan 17, 2025
Pompe disease is a neuromuscular disorder caused by a deficiency of the enzyme acid alpha-glucosidase (), which leads to lysosomal glycogen accumulation and progressive development of muscle weakness. Two distinct isoforms have been identified. In th...
Investigation of alpha-glucosidase inhibition activity of Artabotrys sumatranus leaf extract using metabolomics, machine learning and molecular docking analysis.
PloS one
Jan 3, 2025
One way to treat diabetes mellitus type II is by using α-glucosidase inhibitor, that will slow down the postprandial glucose intake. Metabolomics analysis of Artabotrys sumatranus leaf extract was used in this research to predict the active compounds...
Employing Machine Learning Models to Predict Potential α-Glucosidase Inhibitory Plant Secondary Metabolites Targeting Type-2 Diabetes and Their Validation.
Journal of chemical information and modeling
Oct 1, 2024
The need for new antidiabetic drugs is evident, considering the ongoing global burden of type-2 diabetes mellitus despite notable progress in drug discovery from laboratory research to clinical application. This study aimed to build machine learning ...
Anabasis aretioides Coss. & Moq. phenolic compounds exhibit in vitro hypoglycemic, antioxidant and antipathogenic properties.
Journal of basic and clinical physiology and pharmacology
Dec 20, 2018
Background Based on our previous ethnobotanical survey, the non-investigated Saharan plant Anabasis aretioides Coss. & Moq., growing in the region of Errachidia, was selected for pharmacological investigation. In Moroccan traditional medicine, A. are...
The involvement of phenolic-rich extracts from Galician autochthonous extra-virgin olive oils against the α-glucosidase and α-amylase inhibition.
Food research international (Ottawa, Ont.)
Aug 21, 2018
'Brava' and 'Mansa de Figueiredo' extra-virgin olive oils (EVOOs) are two varieties identified from north-western Spain. A systematic phenolic characterization of the studied oils was undertaken by LC-ESI-IT-MS. In addition, the role of dietary polyp...
α-glucosidase inhibitors isolated from L.
Natural product research
Dec 27, 2017
The aim of the study was to isolate digestive enzymes inhibitors from through a bioassay-guided fractionation approach. Repeated silica gel and sephadex LH 20 column chromatographies of bioactive fractions afforded stigmasterol, quercetin and avicul...
Antioxidant and anti-glycation capacities of some medicinal plants and their potential inhibitory against digestive enzymes related to type 2 diabetes mellitus.
Journal of ethnopharmacology
Dec 21, 2017
ETHNOPHARMACOLOGICAL RELEVANCE: Plants preparations are used by traditional medicine in the treatment of various diseases, such as type-2 diabetes mellitus. Some medicinal plants are capable of controlling the complications of this metabolic disease ...
Physicochemical characterization and in vitro hypoglycemic activities of polysaccharides from Sargassum pallidum by microwave-assisted aqueous two-phase extraction.
International journal of biological macromolecules
Dec 19, 2017
Microwave-assisted aqueous two-phase extraction (MAATPE) was applied for simultaneous extraction and separation of polysaccharides from Sargassum pallidum (SPPs). The optimal extraction parameters, physicochemical properties, and hypoglycemic activit...
Amylases
Sargassum
Monosaccharides
Humans
Microscopy, Atomic Force
Polysaccharides
Chemical Phenomena
Cell Line, Tumor
Liquid-Liquid Extraction
Microwaves
Molecular Conformation
Hypoglycemic Agents
Molecular Weight
alpha-Glucosidases
Glycoside Hydrolase Inhibitors
Spectroscopy, Fourier Transform Infrared
Models, Molecular
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