Creating machine learning models that interpretably link systemic inflammatory index, sex steroid hormones, and dietary antioxidants to identify gout using the SHAP (SHapley Additive exPlanations) method.

Journal: Frontiers in immunology
PMID:

Abstract

BACKGROUND: The relationship between systemic inflammatory index (SII), sex steroid hormones, dietary antioxidants (DA), and gout has not been determined. We aim to develop a reliable and interpretable machine learning (ML) model that links SII, sex steroid hormones, and DA to gout identification.

Authors

  • Shunshun Cao
    Pediatric Endocrinology, Genetics and Metabolism, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Yangyang Hu
    Reproductive Medicine Center, Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.