Point-Of-Care low-field MRI in acute Stroke (POCS): protocol for a multicentric prospective open-label study evaluating diagnostic accuracy.

Journal: BMJ open
PMID: 38296269

Abstract

INTRODUCTION: Fast and accurate diagnosis of acute stroke is crucial to timely initiate reperfusion therapies. Conventional high-field (HF) MRI yields the highest accuracy in discriminating early ischaemia from haemorrhages and mimics. Rapid access to HF-MRI is often limited by contraindications or unavailability. Low-field (LF) MRI (<0.5T) can detect several types of brain injury, including ischaemic and haemorrhagic stroke. Implementing LF-MRI in acute stroke care may offer several advantages, including extended applicability, increased safety, faster administration, reduced staffing and costs. This multicentric prospective open-label trial aims to evaluate the diagnostic accuracy of LF-MRI, as a tool to guide treatment decision in acute stroke.

Authors

  • Matteo Foschi
    Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
  • Angelo Galante
    Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Raffaele Ornello
    Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
  • Stefano Necozione
    Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Carmine Marini
    Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Mario Muselli
    Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Paola Olimpia Achard
    Department of Industrial and Information Engineering and Economics, University of L'Aquila, L'Aquila, Italy.
  • Luciano Fratocchi
    Department of Industrial and Information Engineering and Economics, University of L'Aquila, L'Aquila, Italy.
  • Sergio Lucio Vinci
    Department of Biomorf, University of Messina, UOC Neuroradiology, Messina, Italy.
  • Marco Cavallaro
    Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy.
  • Mauro Silvestrini
    Department of Experimental and Clinical Medicine, Neurological Clinic, Marche Polytechnic University, Ancona, Italy.
  • Gabriele Polonara
    Department of Odontostomatological and Specialized Clinical Sciences, Polytechnic University of Marche, Ancona, Italy.
  • Simona Marcheselli
    Stroke Unit, IRCCS Humanitas Research Hospital, 20089 Milan, Italy.
  • Laura Straffi
    Emergency Neurology and Stroke Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
  • Marco Colasurdo
    Department of Neuroscience and Clinical Sciences, University of Chieti, Chieti, Italy.
  • Luca Sorrentino
    Department of Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori di Milano, Milan, Italy.
  • Enrico Franconi
    Faculty of Computer Science, Free University of Bozen-Bolzano, Bolzano, Italy.
  • Marcello Alecci
    Department of Life, Health & Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
  • Massimo Caulo
    Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University, Via dei Vestini, 66100, Chieti, Italy.
  • Simona Sacco
    Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy simona.sacco@univaq.it.

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