Multi-omics analysis identifies potential microbial and metabolite diagnostic biomarkers of bacterial vaginosis.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV
PMID: 38284174

Abstract

BACKGROUND: Bacterial vaginosis (BV) is a common clinical manifestation of a perturbed vaginal ecology associated with adverse sexual and reproductive health outcomes if left untreated. The existing diagnostic modalities are either cumbersome or require skilled expertise, warranting alternate tests. Application of machine-learning tools to heterogeneous and high-dimensional multi-omics datasets finds promising potential in data integration and may aid biomarker discovery.

Authors

  • A Challa
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
  • J S Maras
    Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
  • S Nagpal
    TCS Research, Tata Consultancy Services Ltd, Pune, India.
  • G Tripathi
    Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
  • B Taneja
    CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
  • G Kachhawa
    Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.
  • S Sood
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
  • B Dhawan
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
  • P Acharya
    College of Medical Sciences, Department of Dermatology, Bharatpur, Nepal, 44200.
  • A D Upadhyay
    Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
  • M Yadav
    Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
  • R Sharma
    Indian Council of Agricultural Research-Indian Institute of Wheat and Barley Research, Karnal, India.
  • M Bajpai
    Department of Transfusion Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
  • S Gupta
    Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Keywords

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