Machine Learning Predicts Oxaliplatin Benefit in Early Colon Cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PMID:

Abstract

PURPOSE: A combination of fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is the standard for adjuvant therapy of resected early-stage colon cancer (CC). Oxaliplatin leads to lasting and disabling neurotoxicity. Reserving the regimen for patients who benefit from oxaliplatin would maximize efficacy and minimize unnecessary adverse side effects.

Authors

  • Lujia Chen
    Department of Biomedical Informatics, University of Pittsburgh, 5607 Baum Blvd, 15237, Pittsburgh, PA, USA. luc17@pitt.edu.
  • Ying Wang
    Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.
  • Chunhui Cai
    Department of Biomedical Informatics, University of Pittsburgh, 5607 Baum Blvd, 15237, Pittsburgh, PA, USA. chunhuic@pitt.edu.
  • Ying Ding
    Cockrell School of Engineering, The University of Texas at Austin, Austin, USA.
  • Rim S Kim
    NSABP/NRG Oncology, Pittsburgh, PA.
  • Corey Lipchik
    NSABP/NRG Oncology, Pittsburgh, PA.
  • Patrick G Gavin
    NSABP/NRG Oncology, Pittsburgh, PA.
  • Greg Yothers
    NRG Oncology Statistics and Data Management Center, Pittsburgh, PA.
  • Carmen J Allegra
    Department of Medicine, University of Florida Health, Gainesville, FL.
  • Nicholas J Petrelli
    Helen F. Graham Cancer Center and Research Institute at Christiana Care, Newark, DE.
  • Jennifer Marie Suga
    Kaiser Permanente Oncology Clinical Trials, KP NCI Community Oncology Research Program (NCORP), Vallejo, CA.
  • Judith O Hopkins
    Novant Health Forsyth Medical Cancer Institute/Southeast Clinical Oncology Research NCORP, Kernersville, NC.
  • Naoyuki G Saito
    Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN.
  • Terry Evans
    UPMC Hillman Cancer Center, Pittsburgh, PA.
  • Srinivas Jujjavarapu
    Illinois CancerCare, P.C./Heartland Cancer Research NCORP, Peoria, IL.
  • Norman Wolmark
    NSABP/NRG Oncology, Pittsburgh, PA.
  • Peter C Lucas
    NSABP/NRG Oncology, Pittsburgh, PA.
  • Soonmyung Paik
    NSABP/NRG Oncology, Pittsburgh, PA.
  • Min Sun
    Division of Oncology, University of Pittsburgh Medical Center Hillman Cancer Center at St. Margaret, 200 Delafield Rd, Pittsburgh, PA, 15215, USA.
  • Katherine L Pogue-Geile
    NSABP/NRG Oncology, Pittsburgh, PA.
  • Xinghua Lu
    Dept. Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.