Development of a robotic cluster for automated and scalable cell therapy manufacturing.

Journal: Cytotherapy
PMID:

Abstract

BACKGROUND AIMS: The production of commercial autologous cell therapies such as chimeric antigen receptor T cells requires complex manual manufacturing processes. Skilled labor costs and challenges in manufacturing scale-out have contributed to high prices for these products.

Authors

  • Alice Melocchi
    Multiply Labs, San Francisco, California, USA; Sezione di Tecnologia e Legislazione Farmaceutiche "M. E. Sangalli", Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Milano, Italy. Electronic address: alice.melocchi@unimi.it.
  • Brigitte Schmittlein
    Multiply Labs, San Francisco, California, USA.
  • Alexis L Jones
    Multiply Labs, San Francisco, California, USA; Department of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  • Yasmine Ainane
    Multiply Labs, San Francisco, California, USA.
  • Ali Rizvi
    Multiply Labs, San Francisco, California, USA.
  • Darius Chan
    Multiply Labs, San Francisco, California, USA.
  • Elaine Dickey
    Multiply Labs, San Francisco, California, USA.
  • Kelsey Pool
    Multiply Labs, San Francisco, California, USA.
  • Kenny Harsono
    Multiply Labs, San Francisco, California, USA.
  • Dorothy Szymkiewicz
    Multiply Labs, San Francisco, California, USA.
  • Umberto Scarfogliero
    Multiply Labs, San Francisco, California, USA.
  • Varun Bhatia
    Multiply Labs, San Francisco, California, USA.
  • Amlesh Sivanantham
    Multiply Labs, San Francisco, California, USA.
  • Nadia Kreciglowa
    Multiply Labs, San Francisco, California, USA.
  • Allison Hunter
    Multiply Labs, San Francisco, California, USA.
  • Miguel Gomez
    Multiply Labs, San Francisco, California, USA.
  • Adrian Tanner
    Multiply Labs, San Francisco, California, USA.
  • Marco Uboldi
    Multiply Labs, San Francisco, California, USA; Sezione di Tecnologia e Legislazione Farmaceutiche "M. E. Sangalli", Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Milano, Italy.
  • Arpit Batish
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Joanna Balcerek
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Mariella Kutova-Stoilova
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Sreenivasan Paruthiyil
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Luis A Acevedo
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Rachel Stadnitskiy
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
  • Sabrina Carmichael
    Cytiva Life Sciences, Marlborough, Massachusetts, USA.
  • Holger Aulbach
    Thermo Fisher Scientific, Langenselbold, Germany.
  • Matthew Hewitt
    Charles River Scientific, Wilmington, Massachusetts, USA.
  • Xavier De Mollerat Du Jeu
    Thermo Fisher Scientific, Carlsbad, California, USA.
  • Benedetta di Robilant
    Dorian Therapeutics, San Francisco, California, USA.
  • Federico Parietti
    Multiply Labs, San Francisco, California, USA.
  • Jonathan H Esensten
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA; The Advanced Biotherapy Center (ABC), Sheba Medical Center, Tel Hashomer, Israel.