AIMC Topic: Cell- and Tissue-Based Therapy
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Machine learning aided UV absorbance spectroscopy for microbial contamination in cell therapy products.
Scientific reports
Mar 4, 2025
We demonstrate the feasibility of machine-learning aided UV absorbance spectroscopy for in-process microbial contamination detection during cell therapy product (CTP) manufacturing. This method leverages a one-class support vector machine to analyse ...
Development of a robotic cluster for automated and scalable cell therapy manufacturing.
Cytotherapy
Mar 15, 2024
BACKGROUND AIMS: The production of commercial autologous cell therapies such as chimeric antigen receptor T cells requires complex manual manufacturing processes. Skilled labor costs and challenges in manufacturing scale-out have contributed to high ...
Robotic cell processing facility for clinical research of retinal cell therapy.
SLAS technology
Oct 29, 2023
The consistent production of high-quality cells in cell therapy highlights the potential of automated manufacturing. Humanoid robots are a useful option for transferring technology to automate human cell cultures. This study evaluated a robotic cell-...
Harnessing the power of artificial intelligence to advance cell therapy.
Immunological reviews
Jul 6, 2023
Cell therapies are powerful technologies in which human cells are reprogrammed for therapeutic applications such as killing cancer cells or replacing defective cells. The technologies underlying cell therapies are increasing in effectiveness and comp...
PPSW-SHAP: Towards Interpretable Cell Classification Using Tree-Based SHAP Image Decomposition and Restoration for High-Throughput Bright-Field Imaging.
Cells
May 13, 2023
Advancements in high-throughput microscopy imaging have transformed cell analytics, enabling functionally relevant, rapid, and in-depth bioanalytics with Artificial Intelligence (AI) as a powerful driving force in cell therapy (CT) manufacturing. Hig...
Personalized Cell Therapy for Patients with Peripheral Arterial Diseases in the Context of Genetic Alterations: Artificial Intelligence-Based Responder and Non-Responder Prediction.
Cells
Nov 23, 2021
Stem/progenitor cell transplantation is a potential novel therapeutic strategy to induce angiogenesis in ischemic tissue, which can prevent major amputation in patients with advanced peripheral artery disease (PAD). Thus, clinicians can use cell ther...
Potential applications of deep learning in single-cell RNA sequencing analysis for cell therapy and regenerative medicine.
Stem cells (Dayton, Ohio)
Feb 15, 2021
When used in cell therapy and regenerative medicine strategies, stem cells have potential to treat many previously incurable diseases. However, current application methods using stem cells are underdeveloped, as these cells are used directly regardle...
A New Era for Cyborg Science Is Emerging: The Promise of Cyborganic Beings.
Advanced healthcare materials
Nov 28, 2019
Living flesh, hacked beyond known biological borders, and sophisticated machineries, made by humans, are currently being united to address some of the impending challenges in medicine. Imagine biological systems made from smart biomaterials with the ...
Improving the Rate of Translation of Tissue Engineering Products.
Advanced healthcare materials
Aug 6, 2019
Over 100 000 research articles and 9000 patents have been published on tissue engineering (TE) in the past 20 years. Yet, very few TE products have made their way to the market during the same period. Experts have proposed a variety of strategies to ...
Optimizing immune cell therapies with artificial intelligence.
Journal of theoretical biology
Oct 22, 2018
PURPOSE: We determine an optimal injection pattern for anti-vascular endothelial growth factor (VEGF) and for the combination of anti-VEGF and unlicensed dendritic cells.
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