AIMC Topic: Cell Culture Techniques

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Re-imagining human cell culture media: Challenges, innovations, and future directions.

Biotechnology advances Mar 16, 2025
The development of optimized culture media is pivotal to advancements in human cell culture, underpinning progress in regenerative medicine, cell therapies, and personalized medicine. While foundational formulations like Eagle's Minimum Essential Med...
Culture Media Regenerative Medicine Cell Culture Techniques Humans Precision Medicine
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Machine Learning-Powered Optimization of a CHO Cell Cultivation Process.

Biotechnology and bioengineering Jan 31, 2025
Chinese Hamster Ovary (CHO) cells are the most widely used cell lines to produce recombinant therapeutic proteins such as monoclonal antibodies (mAbs). However, the optimization of the CHO cell culture process is very complex and influenced by variou...
Cricetinae Cell Culture Techniques Algorithms Cricetulus Animals Antibodies, Monoclonal Recombinant Proteins Neural Networks, Computer CHO Cells Machine Learning
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Recent advances in culture medium design for enhanced production of monoclonal antibodies in CHO cells: A comparative study of machine learning and systems biology approaches.

Biotechnology advances Nov 19, 2024
The production of monoclonal antibodies (mAbs) using Chinese Hamster Ovary (CHO) cells has revolutionized the treatment of numerous diseases, solidifying their position as a cornerstone of the biopharmaceutical industry. However, achieving maximum mA...
Machine Learning Animals CHO Cells Cricetulus Systems Biology Culture Media Antibodies, Monoclonal Cell Culture Techniques
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Rapid total sialic acid monitoring during cell culture process using a machine learning model based soft sensor.

Biotechnology progress Jul 2, 2024
Total sialic acid content (TSA) in biotherapeutic proteins is often a critical quality attribute as it impacts the drug efficacy. Traditional wet chemical assays to quantify TSA in biotherapeutic proteins during cell culture typically takes several h...
Cell Culture Techniques N-Acetylneuraminic Acid Machine Learning Animals CHO Cells Cricetulus
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Reinforcement learning-guided control strategies for CAR T-cell activation and expansion.

Biotechnology and bioengineering May 29, 2024
Reinforcement learning (RL), a subset of machine learning (ML), could optimize and control biomanufacturing processes, such as improved production of therapeutic cells. Here, the process of CAR T-cell activation by antigen-presenting beads and their ...
Cell Culture Techniques Immunotherapy, Adoptive T-Lymphocytes Lymphocyte Activation Humans Machine Learning Computer Simulation Receptors, Chimeric Antigen
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Development of a robotic cluster for automated and scalable cell therapy manufacturing.

Cytotherapy Mar 15, 2024
BACKGROUND AIMS: The production of commercial autologous cell therapies such as chimeric antigen receptor T cells requires complex manual manufacturing processes. Skilled labor costs and challenges in manufacturing scale-out have contributed to high ...
Humans Receptors, Chimeric Antigen CD8-Positive T-Lymphocytes Cell- and Tissue-Based Therapy Robotics Cell Culture Techniques Bioreactors Immunotherapy, Adoptive Automation
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Angio-Net: deep learning-based label-free detection and morphometric analysis of angiogenesis.

Lab on a chip Feb 13, 2024
Despite significant advancements in three-dimensional (3D) cell culture technology and the acquisition of extensive data, there is an ongoing need for more effective and dependable data analysis methods. These concerns arise from the continued relian...
Cell Culture Techniques Angiogenesis Deep Learning
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Prediction of Spheroid Cell Death Using Fluorescence Staining and Convolutional Neural Networks.

Chemical research in toxicology Dec 5, 2023
Three-dimensional (3D) cell culture is emerging for drug design and drug screening. Skin toxicity is one of the most important assays for determining the toxicity of a compound before being used in skin application. Much work has been done to find an...
Cell Culture Techniques Propidium Apoptosis Neural Networks, Computer Animals
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Challenges in developing cell culture media using machine learning.

Biotechnology advances Nov 19, 2023
Microbial and mammalian cells are widely used in the food, pharmaceutical, and medical industries. Developing or optimizing culture media is essential to improve cell culture performance as a critical technology in cell culture engineering. Methodolo...
Mammals Animals Machine Learning Cell Culture Techniques Culture Media
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Robotic cell processing facility for clinical research of retinal cell therapy.

SLAS technology Oct 29, 2023
The consistent production of high-quality cells in cell therapy highlights the potential of automated manufacturing. Humanoid robots are a useful option for transferring technology to automate human cell cultures. This study evaluated a robotic cell-...
Cell Culture Techniques Robotics Retina Induced Pluripotent Stem Cells Humans Cell- and Tissue-Based Therapy Biomedical Research
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