AIMC Topic: Cell Culture Techniques

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Screening of Biomaterials for Stem Cell Culture Applications.

ACS biomaterials science & engineering Jun 9, 2025
Stem cells have a considerable role to play in future biomedical breakthroughs due to their therapeutic potential. As stem cells may be studied in a variety of different applications, a "one size fits all" approach to the stem cell culture substrate ...
Humans Machine Learning Animals Stem Cells Biocompatible Materials Cell Culture Techniques
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A method for evaluating the degree of Adipogenic differentiation of porcine cells cultured in suspension based on deep learning.

Food research international (Ottawa, Ont.) Apr 28, 2025
Fat plays a very important role in the quality of meat and meat products. Cell culture based adipocyte differentiation is a crucial step in the production of cell-cultured meat, traditionally relying on quantitative assessments through fluorescence s...
Cells, Cultured Animals High-Throughput Screening Assays Adipocytes Cell Culture Techniques Adipogenesis Cell Differentiation Swine Deep Learning
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Re-imagining human cell culture media: Challenges, innovations, and future directions.

Biotechnology advances Mar 16, 2025
The development of optimized culture media is pivotal to advancements in human cell culture, underpinning progress in regenerative medicine, cell therapies, and personalized medicine. While foundational formulations like Eagle's Minimum Essential Med...
Humans Precision Medicine Cell Culture Techniques Culture Media Regenerative Medicine
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Machine Learning-Powered Optimization of a CHO Cell Cultivation Process.

Biotechnology and bioengineering Jan 31, 2025
Chinese Hamster Ovary (CHO) cells are the most widely used cell lines to produce recombinant therapeutic proteins such as monoclonal antibodies (mAbs). However, the optimization of the CHO cell culture process is very complex and influenced by variou...
CHO Cells Cricetulus Animals Recombinant Proteins Cell Culture Techniques Antibodies, Monoclonal Cricetinae Neural Networks, Computer Machine Learning Algorithms
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Recent advances in culture medium design for enhanced production of monoclonal antibodies in CHO cells: A comparative study of machine learning and systems biology approaches.

Biotechnology advances Nov 19, 2024
The production of monoclonal antibodies (mAbs) using Chinese Hamster Ovary (CHO) cells has revolutionized the treatment of numerous diseases, solidifying their position as a cornerstone of the biopharmaceutical industry. However, achieving maximum mA...
Cell Culture Techniques Cricetulus Antibodies, Monoclonal Culture Media CHO Cells Animals Systems Biology Machine Learning
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Rapid total sialic acid monitoring during cell culture process using a machine learning model based soft sensor.

Biotechnology progress Jul 2, 2024
Total sialic acid content (TSA) in biotherapeutic proteins is often a critical quality attribute as it impacts the drug efficacy. Traditional wet chemical assays to quantify TSA in biotherapeutic proteins during cell culture typically takes several h...
Cell Culture Techniques CHO Cells Machine Learning N-Acetylneuraminic Acid Cricetulus Animals
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Reinforcement learning-guided control strategies for CAR T-cell activation and expansion.

Biotechnology and bioengineering May 29, 2024
Reinforcement learning (RL), a subset of machine learning (ML), could optimize and control biomanufacturing processes, such as improved production of therapeutic cells. Here, the process of CAR T-cell activation by antigen-presenting beads and their ...
T-Lymphocytes Lymphocyte Activation Cell Culture Techniques Immunotherapy, Adoptive Computer Simulation Receptors, Chimeric Antigen Humans Machine Learning
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Development of a robotic cluster for automated and scalable cell therapy manufacturing.

Cytotherapy Mar 15, 2024
BACKGROUND AIMS: The production of commercial autologous cell therapies such as chimeric antigen receptor T cells requires complex manual manufacturing processes. Skilled labor costs and challenges in manufacturing scale-out have contributed to high ...
CD8-Positive T-Lymphocytes Robotics Humans Receptors, Chimeric Antigen Cell Culture Techniques Immunotherapy, Adoptive Cell- and Tissue-Based Therapy Bioreactors Automation
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Angio-Net: deep learning-based label-free detection and morphometric analysis of angiogenesis.

Lab on a chip Feb 13, 2024
Despite significant advancements in three-dimensional (3D) cell culture technology and the acquisition of extensive data, there is an ongoing need for more effective and dependable data analysis methods. These concerns arise from the continued relian...
Deep Learning Cell Culture Techniques Angiogenesis
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Prediction of Spheroid Cell Death Using Fluorescence Staining and Convolutional Neural Networks.

Chemical research in toxicology Dec 5, 2023
Three-dimensional (3D) cell culture is emerging for drug design and drug screening. Skin toxicity is one of the most important assays for determining the toxicity of a compound before being used in skin application. Much work has been done to find an...
Propidium Cell Culture Techniques Neural Networks, Computer Apoptosis Animals
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