Regional muscle tissue saturation is an indicator of global inadequate circulation during cardiopulmonary bypass: a randomized porcine study using muscle, intestinal and brain tissue metabolomics.

Journal: Perfusion
PMID: 28327077

Abstract

BACKGROUND: Muscle tissue saturation (StO) measured with near-infrared spectroscopy has generally been considered a measurement of the tissue microcirculatory condition. However, we hypothesized that StO could be more regarded as a fast and reliable measure of global than of regional circulatory adequacy and tested this with muscle, intestinal and brain metabolomics at normal and two levels of low cardiopulmonary bypass blood flow rates in a porcine model.

Authors

  • Sisse Anette Thomassen
    1 Department of Anaesthesiology and Intensive Care Medicine, Aalborg University Hospital, Aalborg, Denmark.
  • Benedict Kjærgaard
    2 Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Preben Sørensen
    2 Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Jan Jesper Andreasen
    2 Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Anders Larsson
    5 Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
  • Bodil Steen Rasmussen
    1 Department of Anaesthesiology and Intensive Care Medicine, Aalborg University Hospital, Aalborg, Denmark.

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