Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy.

Journal: Annals of neurology
PMID:

Abstract

OBJECTIVE: To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) to predict the development of Parkinson disease (PD) and dementia with Lewy bodies (DLB).

Authors

  • Dario Arnaldi
    Department of Neuroscience, Rehabilitation, Opthalmology, Genetics and Maternal and Child Science (DINOGMI), University of Genoa Largo Paolo Daneo 3, 16132 Genoa, Italy.
  • Pietro Mattioli
    Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
  • Stefano Raffa
    IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Matteo Pardini
    Department of Neuroscience (DINOGMI), University of Genoa and Neurology Clinics, Polyclinic San Martino Hospital, Genoa, Italy.
  • Federico Massa
    Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
  • Alex Iranzo
    Neurology Service, Multidisciplinary Sleep Unit, Hospital Clínic of Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
  • Andres Perissinotti
    Nuclear Medicine Service, Hospital Clínic Barcelona, Biomedical Research Networking Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), ISCIII, Barcelona, Spain.
  • Aida Niñerola-Baizán
    Nuclear Medicine Service, Hospital Clínic Barcelona, Biomedical Research Networking Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), ISCIII, Barcelona, Spain.
  • Carles Gaig
    Neurology Service, Multidisciplinary Sleep Unit, Hospital Clínic of Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
  • Monica Serradell
    Neurology Service, Sleep Disorder Centre, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain.
  • Amaia Muñoz-Lopetegi
    Neurology Service, Sleep Disorder Centre, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain.
  • Gerard Mayà
    Neurology Service, Sleep Disorder Centre, Hospital Clínic Barcelona, Universitat de Barcelona, IDIBAPS, CIBERNED: CB06/05/0018-ISCIII, Barcelona, Spain.
  • Claudio Liguori
    Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Mariana Fernandes
    Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Fabio Placidi
    Epilepsy Center, Neurology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
  • Agostino Chiaravalloti
    Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
  • Karel Sonka
    Neurology Department and Centre of Clinical Neurosciences, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Petr Dusek
    Department of Neurology, 1st Faculty of Medicine, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University, Prague, Czechia.
  • David Zogala
  • Jiri Trnka
    Institute of Nuclear Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
  • Bradley F Boeve
    Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Toji Miyagawa
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Val J Lowe
    Department of Radiology, Mayo Clinic, Rochester, Minnesota.
  • Tomoyuki Miyamoto
    Department of Neurology, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.
  • Masayuki Miyamoto
    Center of Sleep Medicine, Dokkyo Medical University Hospital, Tochigi, Japan.
  • Monica Puligheddu
    Sleep Disorder Center, Department of Public Health and Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy.
  • Michela Figorilli
    Sleep Disorder Center, Department of Public Health and Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy.
  • Alessandra Serra
    Nuclear Medicine Unit, Department of Medical Science and Public Health, University of Cagliari, Cagliari, Italy.
  • Michele T Hu
    From the Oxford Parkinson's Disease Centre (C.L., S.A., T.R.B., J.C.K., M.T.H.), Nuffield Department of Clinical Neurosciences (C.L., T.R.B., J.C.K., M.T.H.), and Saïd Business School (S.A.), University of Oxford; Population Health Sciences (Y.B.-S., M.L., S.K.), University of Bristol, UK; Department of Neurology (A.J., E.S., W.H.O.), Philipps University Marburg; Institute for Neurogenomics (W.H.O.), München Helmholtz Center for Health and Environment, Neuherberg München, Germany; and Institute of Neurological Sciences (D.G.G.), Queen Elizabeth University Hospital, Glasgow, UK.
  • Johannes C Klein
    From the Oxford Parkinson's Disease Centre (C.L., S.A., T.R.B., J.C.K., M.T.H.), Nuffield Department of Clinical Neurosciences (C.L., T.R.B., J.C.K., M.T.H.), and Saïd Business School (S.A.), University of Oxford; Population Health Sciences (Y.B.-S., M.L., S.K.), University of Bristol, UK; Department of Neurology (A.J., E.S., W.H.O.), Philipps University Marburg; Institute for Neurogenomics (W.H.O.), München Helmholtz Center for Health and Environment, Neuherberg München, Germany; and Institute of Neurological Sciences (D.G.G.), Queen Elizabeth University Hospital, Glasgow, UK.
  • Frederik Bes
    Clinic of Sleep & Chronomedicine, St. Hedwig-Hospital, Berlin, Germany.
  • Dieter Kunz
    Clinic of Sleep & Chronomedicine, St. Hedwig-Hospital, Berlin, Germany.
  • Valérie Cochen De Cock
    Sleep and Neurology Department, Beau Soleil Clinic, Montpellier, France.
  • Delphine de Verbizier
    Nuclear Medicine Unit, University Hospital of Montpellier, Montpellier, France.
  • Giuseppe Plazzi
    Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
  • Elena Antelmi
    Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
  • Michele Terzaghi
    Sleep Medicine and Epilepsy Unit, IRCCS Mondino Foundation, Pavia, Italy.
  • Irene Bossert
    Nuclear Medicine Unit, ICS Maugeri SpA SB IRCCS, Pavia, Italy.
  • Kristína Kulcsárová
    Department of Neurology, P. J. Safarik University, Kosice, Slovak Republic.
  • Alessio Martino
    Department of Business and Management, LUISS University, Rome, Italy.
  • Alessandro Giuliani
    Department of Environment and Health, Istituto Superiore di Sanità, Rome, Italy.
  • Marco Pagani
    f Department of Nuclear Medicine , Karolinska Hospital , Stockholm , Sweden, and.
  • Flavio Nobili
    Department of Neuroscience, Rehabilitation, Opthalmology, Genetics and Maternal and Child Science (DINOGMI), University of Genoa Largo Paolo Daneo 3, 16132 Genoa, Italy.
  • Silvia Morbelli
    IRCCS AOU San Martino - IST, Largo R. Benzi 10, 16132 Genoa, Italy.