Antibody transistor biosensors show promise for early Alzheimer's disease (AD) diagnosis due to their single molecule detection capability. However, the random attachment of a payload to antigen-binding fragments (Fab) during biosensor preparation ca...
, the fruit fly, uses the neurotransmitters dopamine and octopamine to mediate learning, enabling adaptive behaviors such as reward seeking and punishment avoidance. Their colocalization in the mushroom bodies makes it challenging to study their indi...
Rapid, accurate, and renewable electrochemiluminescence (ECL) bioassays are crucial for multiplexed biomarker detection. Integrated with efficient analytical model for processing sensing data, these tools enable precise differentiation of tumor stage...
Langmuir : the ACS journal of surfaces and colloids
Oct 8, 2025
Dopamine (DA) plays a pivotal role in modulating various physiological systems. Therefore, the ultrasensitive detection of DA holds substantial importance for the diagnosis and treatment of neurological disorders. Herein, a deep-learning-assisted sma...
Neural cells reside in a three-dimensional (3D) microenvironment where the structure of the nerve circuitry is shaped by the morphology and stiffness of the surrounding extracellular matrix. In this environment, regular exposure to varying mechanical...
Analytical methods : advancing methods and applications
Sep 25, 2025
Simultaneous monitoring of catecholamine neurotransmitters (CNTs)-including epinephrine (Epi), norepinephrine (NE), levodopa (L-DOPA), and dopamine (DA)-is essential for the accurate diagnosis and effective management of various neurological disorder...
Simultaneous monitoring of dopamine (DA) and serotonin (SER) in urine offers a non-invasive route for diagnosing neurological, psychiatric, and metabolic disorders. However, their multiplexed detection at the point-of-care remains challenging due to ...
Analytical methods : advancing methods and applications
Jul 17, 2025
Metabolic molecules are highly correlated with various physiological indicators and diseases, so it is particularly important to monitor the levels of multiple metabolites in the body. Due to the similar electrochemical properties of uric acid (UA), ...
CPT: pharmacometrics & systems pharmacology
Mar 5, 2025
Approximately 15% of patients suspected of having Parkinson's disease (PD) present dopamine active transporter (DaT) scans without evidence of dopaminergic deficits (SWEDD), most of which will never develop PD. Leveraging Movement Disorders Society U...
Optical nanosensors, including single-walled carbon nanotubes (SWCNTs), provide real-time spatiotemporal reporting at the single-molecule level within a nanometer-scale area. However, their superior sensitivity also makes them susceptible to slight e...
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