AIMC Topic: Synucleinopathies

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Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy.

Annals of neurology Mar 11, 2024
OBJECTIVE: To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) to predict the development of Parkinson disease (PD) and dementia with Lewy ...
Humans Machine Learning Female Aged Male Middle Aged Parkinson Disease Lewy Body Disease Dopamine Tomography, Emission-Computed, Single-Photon Synucleinopathies Presynaptic Terminals REM Sleep Behavior Disorder Dopaminergic Imaging
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EEG-based machine learning models for the prediction of phenoconversion time and subtype in isolated rapid eye movement sleep behavior disorder.

Sleep May 10, 2024
STUDY OBJECTIVES: Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of α-synucleinopathies and eventually phenoconverts to overt neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies (D...
Humans Machine Learning Female Aged Male Middle Aged Disease Progression Electroencephalography Lewy Body Disease Prodromal Symptoms Synucleinopathies REM Sleep Behavior Disorder
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Automatic substantia nigra segmentation in neuromelanin-sensitive MRI by deep neural network in patients with prodromal and manifest synucleinopathy.

Physiological research Dec 30, 2019
Neuromelanin (NM) is a black pigment located in the brain in substantia nigra pars compacta (SN) and locus coeruleus. Its loss is directly connected to the loss of nerve cells in this part of the brain, which plays a role in Parkinson's Disease. Magn...
Humans Female Aged Male Middle Aged Case-Control Studies Deep Learning Image Processing, Computer-Assisted Magnetic Resonance Imaging Substantia Nigra Melanins Prodromal Symptoms Synucleinopathies
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