AIMC Topic: Synucleinopathies

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Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy.

Annals of neurology Mar 11, 2024
OBJECTIVE: To apply a machine learning analysis to clinical and presynaptic dopaminergic imaging data of patients with rapid eye movement (REM) sleep behavior disorder (RBD) to predict the development of Parkinson disease (PD) and dementia with Lewy ...
Dopaminergic Imaging Aged Middle Aged Male Synucleinopathies Machine Learning Tomography, Emission-Computed, Single-Photon Female REM Sleep Behavior Disorder Parkinson Disease Humans Lewy Body Disease Presynaptic Terminals Dopamine
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Contribution of α-synuclein cytopathologies to distinct seeding of misfolded α-synuclein.

Brain pathology (Zurich, Switzerland) Nov 1, 2025
Synucleinopathies are a group of neurodegenerative diseases characterized by the deposition of misfolded α-synuclein (αSyn), predominantly in oligodendrocytes in multiple system atrophy (MSA) and in neurons in Lewy body diseases (LBD). The contributi...
alpha-Synuclein Neurons Aged Middle Aged Male Oligodendroglia Synucleinopathies Aged, 80 and over Multiple System Atrophy Lewy Body Disease Brain Humans Female
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EEG-based machine learning models for the prediction of phenoconversion time and subtype in isolated rapid eye movement sleep behavior disorder.

Sleep May 10, 2024
STUDY OBJECTIVES: Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of α-synucleinopathies and eventually phenoconverts to overt neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies (D...
Disease Progression Electroencephalography Middle Aged Synucleinopathies REM Sleep Behavior Disorder Prodromal Symptoms Lewy Body Disease Female Male Aged Humans Machine Learning
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Automatic substantia nigra segmentation in neuromelanin-sensitive MRI by deep neural network in patients with prodromal and manifest synucleinopathy.

Physiological research Dec 30, 2019
Neuromelanin (NM) is a black pigment located in the brain in substantia nigra pars compacta (SN) and locus coeruleus. Its loss is directly connected to the loss of nerve cells in this part of the brain, which plays a role in Parkinson's Disease. Magn...
Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Melanins Deep Learning Synucleinopathies Prodromal Symptoms Substantia Nigra Female Case-Control Studies Middle Aged Humans Aged
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