Combined blood Neurofilament light chain and third ventricle width to differentiate Progressive Supranuclear Palsy from Parkinson's Disease: A machine learning study.

Journal: Parkinsonism & related disorders
PMID: 38678852

Abstract

INTRODUCTION: Differentiating Progressive Supranuclear Palsy (PSP) from Parkinson's Disease (PD) may be clinically challenging. In this study, we explored the performance of machine learning models based on MR imaging and blood molecular biomarkers in distinguishing between these two neurodegenerative diseases.

Authors

  • Maria Giovanna Bianco
    Neuroscience Research Centre, Department of Medical and Surgical Sciences, Magna Graecia University, Viale Europa, Germaneto, 88100, Catanzaro, Italy.
  • Costanza Maria Cristiani
    Experimental and Clinic Medicine, Department of Experimental and Clinical Medicine, "Magna Graecia" University, Catanzaro, Italy.
  • Luana Scaramuzzino
    Neuroscience Research Center, Department of Medical and Surgical Sciences, University "Magna Graecia", Catanzaro, Italy.
  • Alessia Sarica
    Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 88100 Catanzaro, Italy.
  • Antonio Augimeri
    Biotecnomed S.c.a.r.l, Catanzaro, Italy.
  • Ilaria Chimento
    Neuroscience Research Center, Department of Medical and Surgical Sciences, University "Magna Graecia", Catanzaro, Italy.
  • Jolanda Buonocore
    Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
  • Elvira Immacolata Parrotta
    Institute of Molecular Biology, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy.
  • Andrea Quattrone
    Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.
  • Gianni Cuda
    Department of Clinical and Experimental Medicine, University Magna Graecia, Catanzaro, Italy.
  • Aldo Quattrone
    Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 88100 Catanzaro, Italy; Institute of Neurology, Department of Medicine, "Magna Graecia" University, 88100 Catanzaro, Italy.

Keywords

External Resources

Popular Topics
Recent Journals