Identification of BGN positive fibroblasts as a driving factor for colorectal cancer and development of its related prognostic model combined with machine learning.

Journal: BMC cancer
PMID:

Abstract

BACKGROUND: Numerous studies have indicated that cancer-associated fibroblasts (CAFs) play a crucial role in the progression of colorectal cancer (CRC). However, there are still many unknowns regarding the exact role of CAF subtypes in CRC.

Authors

  • Shangshang Hu
    School of Medicine, Southeast University, 210009, Nanjing, Jiangsu, China.
  • Qianni Xiao
    School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211122, Nanjing, Jiangsu, China.
  • Rui Gao
    School of Control Science and Engineering, Shandong University, Jinan, China.
  • Jian Qin
    College of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China.
  • Junjie Nie
    School of Medicine, Southeast University, 210009, Nanjing, Jiangsu, China.
  • Yuhan Chen
    Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
  • Jinwei Lou
    School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211122, Nanjing, Jiangsu, China.
  • Muzi Ding
    School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211122, Nanjing, Jiangsu, China.
  • Yuqin Pan
    General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, No. 68, Changle Road, 210006, Nanjing, Jiangsu, China. panyuqin01@163.com.
  • Shukui Wang
    School of Medicine, Southeast University, 210009, Nanjing, Jiangsu, China. sk_wang@njmu.edu.cn.