AIMC Topic: Biglycan

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Identification of BGN positive fibroblasts as a driving factor for colorectal cancer and development of its related prognostic model combined with machine learning.

BMC cancer Apr 23, 2024
BACKGROUND: Numerous studies have indicated that cancer-associated fibroblasts (CAFs) play a crucial role in the progression of colorectal cancer (CRC). However, there are still many unknowns regarding the exact role of CAF subtypes in CRC.
Humans Machine Learning Prognosis Female Colorectal Neoplasms Tumor Microenvironment Biomarkers, Tumor Male Gene Expression Regulation, Neoplastic Cell Proliferation Cell Movement Cancer-Associated Fibroblasts Biglycan
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Deep learning neural network image analysis of immunohistochemical protein expression reveals a significantly reduced expression of biglycan in breast cancer.

PloS one Mar 27, 2023
New breast cancer biomarkers have been sought for better tumor characterization and treatment. Among these putative markers, there is Biglycan (BGN). BGN is a class I small leucine-rich proteoglycan family of proteins characterized by a protein core ...
Humans Neural Networks, Computer Female Breast Neoplasms Biomarkers, Tumor Case-Control Studies Deep Learning Image Interpretation, Computer-Assisted Biglycan
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