Machine Learning-Based Perivascular Space Volumetry in Alzheimer Disease.

Journal: Investigative radiology
Published Date:

Abstract

OBJECTIVES: Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when the anatomy of the perivascular space (PVS) is altered during AD progression. Therefore, this study investigates the association between PVS volume and AD progression in cognitively unimpaired (CU) individuals, both with and without subjective cognitive decline (SCD), and in those clinically diagnosed with mild cognitive impairment (MCI) or mild AD.

Authors

  • Katerina Deike
    From the German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany (K.D., A.D., K.F., O.K., F.J., Annika Spottke, N.R., M.W., S.R., M.T.H., F.B., Alfredo Ramirez, S.W., L.K., M.S., M.C.S., G.C.P., Anja Schneider, Alexander Radbruch); Department of Neuroradiology, University Hospital, Bonn, Germany (K.D., P.S., D.P., Alexander Radbruch); Department of Neurodegenerative Disease and Geriatric Psychiatry/Psychiatry, University Hospital Bonn, Bonn, Germany (J.H., N.Z., K.F., M.W., Alfredo Ramirez, S.W., L.K., Anja Schneider); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (D.P.); German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany (O.P., S.D.F., J.P., E.S., S.A.); Institute of Psychiatry and Psychotherapy, Charité-Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany (O.P., S.D.F., L.-S.S., L.P.); Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany (J.P., E.S., S.A., A.L.); Department of Psychiatry and Psychotherapy, School of Medicine, Munich, Germany (J.P.); University of Edinburgh and UK DRI, Edinburgh, United Kingdom (J.P.); German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany (J.W.); Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen, Germany (J.W., C.B., N.H.); Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal (J.W.); Department of Psychiatry, University of Cologne, Cologne, Germany (F.J., Ayda Rostamzadeh); Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany (F.J., Alfredo Ramirez); German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany (E.D., W.G., E.I.I., Michaela Butryn, L.D., R.Y.); Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany (E.D., W.G., E.I.I., Michaela Butryn); Department for Psychiatry and Psychotherapy, University Clinic Magdeburg, Magdeburg, Germany (E.I.I.); German Center for Neurodegenerative Diseases (DZNE), Munich, Germany (K.B., M.E., R.P.); Institute for Stroke and Dementia Research, LMU Munich, Germany (K.B., D.J., M.E.); Department of Psychiatry and Psychotherapy, LMU Munich, Germany (R.P., B.-S.R.); Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (R.P.); Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United Kingdom (R.P.); Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, United Kingdom (R.P., B.-S.R.); Department of Neuroradiology, University Hospital Munich, Munich, Germany (B.-S.R.); German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany (S.T., I.K., D.G.); Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany (S.T., I.K., D.G.); German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany (C.L., M.H.M.); Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, Tübingen, Germany (C.L.); Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen Germany (M.H.M.); Department of Neurology, University of Bonn, Bonn, Germany (Annika Spottke); Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Cologne, Germany (Alfredo Ramirez); Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX (Alfredo Ramirez); Institute for Medical Biometry, Informatics, and Epidemiology, University Hospital Bonn, Bonn, Germany (M.C.S., Moritz Berger); Berlin Center for Advanced Neuroimaging, Charité-Universitätsmedizin, Berlin, Germany (S.H.); MR-Research in Neurosciences, Department of Cognitive Neurology, Göttingen, Germany (P.D.); Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany (K.S.); Division of Vascular Neurology, Department of Neurology, University Hospital Bonn, Bonn, Germany (G.C.P.); and Institute for Applied Mathematics, University of Bonn, Bonn, Germany (A.E.).
  • Andreas Decker
  • Paul Scheyhing
  • Julia Harten
  • Nadine Zimmermann
  • Daniel Paech
  • Oliver Peters
  • Silka D Freiesleben
  • Luisa-Sophie Schneider
  • Lukas Preis
  • Josef Priller
  • Eike Spruth
  • Slawek Altenstein
  • Andrea Lohse
  • Klaus Fliessbach
    Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Bonn, Germany.
  • Okka Kimmich
  • Jens Wiltfang
    Department of Psychiatry and Psychotherapy (NH, HE, JW), University of Göttingen Medical Center, Göttingen, Germany; German Center for Neurodegenerative Diseases (DZNE) (JW), Göttingen, Germany; Neurosciences and Signaling Group (JW), Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
  • Claudia Bartels
  • Niels Hansen
    Department of Psychiatry and Psychotherapy (NH, HE, JW), University of Göttingen Medical Center, Göttingen, Germany.
  • Frank Jessen
    Clinic and Polyclinic for Psychiatry and Psychotherapy, University of Bonn, Germany.
  • Ayda Rostamzadeh
  • Emrah Düzel
    German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
  • Wenzel Glanz
  • Enise I Incesoy
  • Michaela Butryn
  • Katharina Buerger
  • Daniel Janowitz
  • Michael Ewers
    Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.
  • Robert Perneczky
    Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College of Science, Technology and Medicine London, United Kingdom.
  • Boris-Stephan Rauchmann
  • Stefan Teipel
    Departments of Psychosomatic Medicine, University of Rostock, and German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
  • Ingo Kilimann
  • Doreen Goerss
  • Christoph Laske
  • Matthias H Munk
  • Annika Spottke
  • Nina Roy
  • Michael Wagner
  • Sandra Roeske
  • Michael T Heneka
  • Frederic Brosseron
  • Alfredo Ramirez
  • Laura Dobisch
  • Steffen Wolfsgruber
  • Luca Kleineidam
  • Renat Yakupov
  • Melina Stark
  • Matthias C Schmid
  • Moritz Berger
    Institute of Biomedical Statistics, Computer Science and Epidemiology, University of Bonn, Bonn, Germany.
  • Stefan Hetzer
  • Peter Dechent
    Department of Cognitive Neurology, Georg-August-University Goettingen.
  • Klaus Scheffler
    High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
  • Gabor C Petzold
  • Anja Schneider
    Clinic for Psychiatry and Psychotherapy, University of Goettingen, Germany.
  • Alexander Effland
    Institute for Numerical Simulation, University of Bonn, Bonn, Germany. alexander.effland@ins.uni-bonn.de.
  • Alexander Radbruch
    Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany; Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.