Machine learning-based characterization of the gut microbiome associated with the progression of primary biliary cholangitis to cirrhosis.

Journal: Microbes and infection
PMID:

Abstract

BACKGROUND: Primary biliary cholangitis (PBC) is associated closely with the gut microbiota. This study aimed to explore the characteristics of the gut microbiota after the progress of PBC to cirrhosis.

Authors

  • Qi Wang
    Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Xiaomeng Tang
    Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, PR China; Beijing Institute of Infectious Diseases, Beijing, PR China; National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, PR China.
  • Wenying Qiao
    Department of Cancer Center, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Lina Sun
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
  • Han Shi
    College of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao 266061, China; Artificial Intelligence and Biomedical Big Data Research Center, Qingdao University of Science and Technology, Qingdao 266061, China; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
  • Dexi Chen
    Beijing Institute of Hepatology, Beijing You 'an Hospital, Capital Medical University, Beijing 100069, PR China.
  • Bin Xu
    Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
  • Yanmin Liu
    Second Department of Liver Disease Center, Beijing You 'an Hospital, Capital Medical University, Beijing 100069, PR China.
  • Juan Zhao
    Hefei University, Hefei, China.
  • Chunyang Huang
    Second Department of Liver Disease Center, Beijing You 'an Hospital, Capital Medical University, Beijing 100069, PR China. Electronic address: ywgzz188@ccmu.edu.cn.
  • Ronghua Jin
    National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.