A machine learning predictive model for recurrence of resected distal cholangiocarcinoma: Development and validation of predictive model using artificial intelligence.

Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
PMID: 38795677

Abstract

INTRODUCTION: Distal Cholangiocarcinoma (dCCA) represents a challenge in hepatobiliary oncology, that requires nuanced post-resection prognostic modeling. Conventional staging criteria may oversimplify dCCA complexities, prompting the exploration of novel prognostic factors and methodologies, including machine learning algorithms. This study aims to develop a machine learning predictive model for recurrence after resected dCCA.

Authors

  • Marc Perez
    Hepato Pancreato Biliary Division, Hospital Del Mar, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: marcpxaus@gmail.com.
  • Carsten Palnaes Hansen
    Department of Surgery, Rigshospitalet, University of Copenhagen, Denmark. Electronic address: Carsten.Palnaes.Hansen@regionh.dk.
  • Fernando Burdío
    General Surgery Department, Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain.
  • Patricia Sánchez-Velázquez
    General Surgery Department, Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain.
  • Antonio Giuliani
    Unit of General Surgery, San Giuseppe Moscati Hospital, Aversa, Italy. Electronic address: giuldoc@hotmail.com.
  • Francesco Lancellotti
    Department of Hepato-Pancreato-Biliary Surgery, Manchester Royal Infirmary, University of Manchester, Manchester, United Kingdom. Electronic address: francesco.lancellotti87@gmail.com.
  • Nicola de Liguori-Carino
    Department of Hepato-Pancreato-Biliary Surgery, Manchester Royal Infirmary, University of Manchester, Manchester, United Kingdom. Electronic address: Nicola.DeLiguoriCarino@mft.nhs.uk.
  • Giuseppe Malleo
    General Surgery B, The Pancreas Institute, Verona University Hospital Trust, Piazzale L.A. Scuro, 10, 37134, Verona, Italy.
  • Giovanni Marchegiani
    General Surgery B, The Pancreas Institute, Verona University Hospital Trust, Piazzale L.A. Scuro, 10, 37134, Verona, Italy.
  • Mauro Podda
    Department of Surgical Science, University of Cagliari, Cagliari, Italy. Electronic address: mauropodda@ymail.com.
  • Adolfo Pisanu
    Department of Surgical Science, University of Cagliari, Cagliari, Italy. Electronic address: adolfo.pisanu@unica.it.
  • Giuseppe Massimiliano De Luca
    University of Bari "A. Moro", Department of Biomedical Sciences and Human Oncology, Unit of Academic General Surgery " V. Bonomo", Bari, Italy. Electronic address: max-de-luca@libero.it.
  • Alessandro Anselmo
    Department of Surgery, HPB and Transplant Surgery Unit, Policlinico Tor Vergata, Rome, Italy. Electronic address: alessandroanselmo.ptv@gmail.com.
  • Leandro Siragusa
    Department of Surgical Sciences, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy.
  • Stefan Kobbelgaard Burgdorf
    Department of Surgery, Rigshospitalet, University of Copenhagen, Denmark. Electronic address: stefan.kobbelgaard.burgdorf.02@regionh.dk.
  • Christoph Tschuor
    Department of Surgery and Transplantation, Swiss Hepato-Pancreato-Biliary (HPB) Center, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.
  • Andrea Benedetti Cacciaguerra
    HPB Surgery and Transplantation Unit, Department of Clinical and Experimental Medicine, Polytechnic University of Marche, Ancona, Italy. Electronic address: dott.benedetti@gmail.com.
  • Ye Xin Koh
    Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.
  • Yoshio Masuda
    Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore. Electronic address: y.masuda@u.nus.edu.
  • Mark Yeo Hao Xuan
    HPB Unit, Department of Surgery, Cantonal Hospital of Winterthur, Winterthur, Switzerland. Electronic address: markyeohx@u.nus.edu.
  • Nico Seeger
    HPB Unit, Department of Surgery, Cantonal Hospital of Winterthur, Winterthur, Switzerland. Electronic address: nico.seeger@ksw.ch.
  • Stefan Breitenstein
    Department of Surgery, Cantonal Hospital of Winterthur, Brauerstrasse 15, 8401, Winterthur, Switzerland. stefan.breitenstein@ksw.ch.
  • Filip Lukasz Grochola
    HPB Unit, Department of Surgery, Cantonal Hospital of Winterthur, Winterthur, Switzerland. Electronic address: lukaszfilip.grochola@ksw.ch.
  • Marcello Di Martino
    Department of Health Sciences, University of Piemonte Orientale, Novara, Italy. Electronic address: marcello.dimartino@uniupo.it.
  • Luis Secanella
    University Hospital Bellvitge, Barcelona, Spain. Electronic address: lsecanella@bellvitgehospital.cat.
  • Juli Busquets
    University Hospital Bellvitge, Barcelona, Spain. Electronic address: jbusquets@bellvitgehospital.cat.
  • Dimitri Dorcaratto
    Department of General Surgery, Biomedical Research Institute INCLIVA, Hospital Clínico Universitario, University of Valencia, Spain. Electronic address: dorcaratto.dimitri@gmail.com.
  • Isabel Mora-Oliver
    Department of General Surgery, Biomedical Research Institute INCLIVA, Hospital Clínico Universitario, University of Valencia, Spain. Electronic address: isab_mora@hotmail.com.
  • Sara Ingallinella
    Hepatobiliary Surgery Division, San Raffaele Hospital, Milano, Italy. (all authors).
  • Roberto Salvia
    General Surgery B, The Pancreas Institute, Verona University Hospital Trust, Piazzale L.A. Scuro, 10, 37134, Verona, Italy.
  • Mohammad Abu Hilal
    Department of General Surgery, Istituto Ospedaliero Fondazione Poliambulanza.
  • Luca Aldrighetti
    Division of Hepatobiliary Surgery, IRCCS San Raffaele Hospital, Milano, Italy.
  • Benedetto Ielpo
    Hepato Pancreato Biliary Division, Hospital Del Mar, Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: ielpo.b@gmail.com.

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