Prediction of Alzheimer's disease progression within 6 years using speech: A novel approach leveraging language models.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
PMID:

Abstract

INTRODUCTION: Identification of individuals with mild cognitive impairment (MCI) who are at risk of developing Alzheimer's disease (AD) is crucial for early intervention and selection of clinical trials.

Authors

  • Samad Amini
    Department of Electrical & Computer Engineering, Division of Systems Engineering, and Department of Biomedical Engineering, Boston University, Boston, MA, USA.
  • Boran Hao
    Department of Electrical & Computer Engineering, Division of Systems Engineering, and Department of Biomedical Engineering, Boston University, Boston, MA, USA.
  • Jingmei Yang
    Division of System EngineeringBoston University Boston MA 02246 USA.
  • Cody Karjadi
    Framingham Heart Study, Boston University, Boston, MA, USA.
  • Vijaya B Kolachalama
    1Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118 USA.
  • Rhoda Au
    Boston University School of Medicine, rhodaau@bu.edu.
  • Ioannis C Paschalidis
    From the Department of Medicine (M.F.R., R.A., V.B.K.), Boston University Chobanian & Avedisian School of Medicine, MA; Department of Radiology and Biomedical Imaging (M.F.R.), University of California, San Francisco; Department of Neurology (L.C.S., R.A.), Boston University Chobanian & Avedisian School of Medicine; Department of Electrical and Computer Engineering (I.C.P.), Division of Systems Engineering, and Department of Biomedical Engineering; Faculty of Computing and Data Sciences (I.C.P., V.B.K.), Boston University; Department of Anatomy and Neurobiology (R.A.); The Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine; Department of Epidemiology, Boston University School of Public Health; Boston University Alzheimer's Disease Research Center (R.A.); and Department of Computer Science (V.B.K.), Boston University, MA.