D-MAINS: A Deep-Learning Model for the Label-Free Detection of Mitosis, Apoptosis, Interphase, Necrosis, and Senescence in Cancer Cells.

Journal: Cells
PMID: 38920634

Abstract

BACKGROUND: Identifying cells engaged in fundamental cellular processes, such as proliferation or living/death statuses, is pivotal across numerous research fields. However, prevailing methods relying on molecular biomarkers are constrained by high costs, limited specificity, protracted sample preparation, and reliance on fluorescence imaging.

Authors

  • Sarah He
    Department of Biological Sciences, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA.
  • Muhammed Sillah
    Hillman Cancer Center, UPMC, 5115 Center Avenue, Pittsburgh, PA 15232, USA.
  • Aidan R Cole
    Hillman Cancer Center, UPMC, 5115 Center Avenue, Pittsburgh, PA 15232, USA.
  • Apoorva Uboveja
    Hillman Cancer Center, UPMC, 5115 Center Avenue, Pittsburgh, PA 15232, USA.
  • Katherine M Aird
    Hillman Cancer Center, UPMC, 5115 Center Avenue, Pittsburgh, PA 15232, USA.
  • Yu-Chih Chen
  • Yi-Nan Gong
    UPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, Pennsylvania15232, United States.

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