Sex dimorphism of IL-17-secreting peripheral blood mononuclear cells in ankylosing spondylitis based on bioinformatics analysis and machine learning.

Journal: BMC musculoskeletal disorders
PMID: 38914997

Abstract

BACKGROUND: Ankylosing spondylitis (AS) with radiographic damage is more prevalent in men than in women. IL-17, which is mainly secreted from peripheral blood mononuclear cells (PBMCs), plays an important role in the development of AS. Its expression is different between male and female. However, it is still unclear whether sex dimorphism of IL-17 contribute to sex differences in AS.

Authors

  • Sifang Li
    Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, China.
  • Hua Chao
    Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, China.
  • Zihao Li
    School of Mechanical Engineering and Automation, Harbin Institute of Technology(Shenzhen), Shenzhen, 518055, China.
  • Siwen Chen
    Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, China.
  • Jingyu Zhang
    Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China.
  • Wenjun Hao
    Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, China.
  • Shuai Zhang
    School of Information, Zhejiang University of Finance and Economics, Hangzhou, China.
  • Caijun Liu
    Department of Spine Surgery, The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510378, China. liucaijun2005@163.com.
  • Hui Liu
    Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

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