AIMC Topic: Interleukin-17

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Identification of novel IL17-related genes as prognostic and therapeutic biomarkers of psoriasis using comprehensive bioinformatics analysis and machine learning.

Scientific reports Apr 2, 2025
Psoriasis is a common chronic skin disorder with a polygenic background. It is widely acknowledged that Th17/IL-17A axis plays a key role in the pathogenesis of psoriasis. However, numerous regulatory genes upstream of the pathway remain undiscovered...
Prognosis Female Adult Male Interleukin-17 Humans Machine Learning Biomarkers Computational Biology Psoriasis Th17 Cells Receptors, CCR7
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Plasma IL-17A is increased in patients with critical MIS-C and associated to in-hospital mortality.

Frontiers in immunology Jan 27, 2025
BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe post-COVID-19 complication with multiple phenotypes.
Infant ROC Curve Adolescent Female Child, Preschool Interleukin-17 Humans Infant, Newborn Child Hospital Mortality COVID-19 SARS-CoV-2 Prospective Studies Systemic Inflammatory Response Syndrome Male Biomarkers Intensive Care Units, Pediatric Oxidative Stress
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Sex dimorphism of IL-17-secreting peripheral blood mononuclear cells in ankylosing spondylitis based on bioinformatics analysis and machine learning.

BMC musculoskeletal disorders Jun 24, 2024
BACKGROUND: Ankylosing spondylitis (AS) with radiographic damage is more prevalent in men than in women. IL-17, which is mainly secreted from peripheral blood mononuclear cells (PBMCs), plays an important role in the development of AS. Its expression...
Gene Expression Profiling Interleukin-17 Computational Biology Databases, Genetic Sex Characteristics Machine Learning Female Male Leukocytes, Mononuclear Spondylitis, Ankylosing Humans
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PepScaf: Harnessing Machine Learning with In Vitro Selection toward De Novo Macrocyclic Peptides against IL-17C/IL-17RE Interaction.

Journal of medicinal chemistry Jul 22, 2023
The combination of library-based screening and artificial intelligence (AI) has been accelerating the discovery and optimization of hit ligands. However, the potential of AI to assist in de novo macrocyclic peptide ligand discovery has yet to be full...
Artificial Intelligence Machine Learning Peptides Interleukin-17 Peptide Library
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The involvement of gut microbiota in the anti-tumor effect of carnosic acid via IL-17 suppression in colorectal cancer.

Chemico-biological interactions Aug 1, 2022
Colorectal cancer (CRC) is a malignant tumor that threatens human health worldwide. Disturbance of the gut microbiota caused by various external factors is one of the leading causes. Carnosic acid (CA) is a phenolic diterpene compound, mainly isolate...
Humans Colorectal Neoplasms Animals Interleukin-17 Mice Gastrointestinal Microbiome Abietanes
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Placental CD4 T cells isolated from preeclamptic women cause preeclampsia-like symptoms in pregnant nude-athymic rats.

Pregnancy hypertension Nov 2, 2018
Preeclampsia (PE), new onset hypertension during pregnancy, is associated with a proinflammatory profile compared to normal pregnancy (NP). We hypothesize that CD4 T cells from PE patient placentas cause PE symptoms during pregnancy compared to those...
Female Young Adult Adult Animals Real-Time Polymerase Chain Reaction Humans Tumor Necrosis Factor-alpha Placenta Pregnancy CD4-Positive T-Lymphocytes Rats, Nude Pre-Eclampsia Interleukin-17 Vascular Endothelial Growth Factor Receptor-1 Arterial Pressure Rats Placentation Enzyme-Linked Immunosorbent Assay Disease Models, Animal
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Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap: a network approach.

International journal of chronic obstructive pulmonary disease Feb 12, 2018
INTRODUCTION: The asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a clinical condition that combines features of those two diseases, and that is difficult to define due to the lack of understanding of the underlying mechanisms. D...
Interleukin-13 Interleukin-5 Th2 Cells Prognosis Forced Expiratory Volume Female Inflammation Mediators Aged Cell Adhesion Molecules Adult Spain Pulmonary Disease, Chronic Obstructive Vital Capacity Lung Asthma Cross-Sectional Studies Interleukin-17 Male Humans Interleukin-8 Middle Aged Neural Networks, Computer Discriminant Analysis Tumor Necrosis Factor-alpha Interleukin-6 Biomarkers
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Inflammatory bowel disease patients experiencing a loss of response to infliximab regain long-term response after undergoing granulocyte/monocyte apheresis: A case series.

Cytokine Dec 29, 2017
Up to 50% of patients with ulcerative colitis (UC) or Crohn's disease (CD) experience a loss of response (LOR) to infliximab after an initial response to the drug. Granulocyte/monocyte apheresis (GMA) with the Adacolumn depletes the activated myeloid...
Time Factors Interleukin-17 Colitis, Ulcerative C-Reactive Protein Infliximab Leukapheresis Prospective Studies Female Adult Male Middle Aged Humans Interleukin-6
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Decoding chronic stress: From behavioral-molecular dynamics in mice to clinical implications of cortisol and IL-17 in depression severity.

Journal of affective disorders Sep 15, 2025
BACKGROUNDS: The etiology of depression involves chronic stress, a recognized determinant of onset and severity. This study adopts a translational approach, utilizing a mouse model and a clinical cohort to explore the relationship between chronic str...
Mice, Inbred C57BL Chronic Disease Animals Hydrocortisone Male Middle Aged Humans Severity of Illness Index Depression Machine Learning Stress, Psychological Biomarkers Interleukin-17 Female Mice Adult Disease Models, Animal
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Big data-driven target identification by machine learning: DRD2 as a therapeutic target for psoriasis.

Journal of dermatological science Jul 1, 2025
BACKGROUND: The development of medical treatments has traditionally relied on researchers leveraging scientific knowledge to hypothesize disease mechanisms and identify therapeutic agents. However, the depletion of novel therapeutic targets has becom...
Machine Learning Tumor Necrosis Factor-alpha Animals Drug Discovery Big Data Humans Skin Imiquimod Molecular Targeted Therapy Dopamine Agonists Receptors, Dopamine D2 Interleukin-17 Mice Disease Models, Animal Psoriasis
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