Development and Validation Study of the Prognostic Impact of Deep Learning-Determined Myxoid Stroma After Neoadjuvant Chemotherapy in Patients with Esophageal Squamous Cell Carcinoma.

Journal: Annals of surgical oncology
PMID:

Abstract

PURPOSE: This study was designed to investigate the prognostic significance of artificial intelligence (AI)-based quantification of myxoid stroma in patients undergoing esophageal squamous cell carcinoma (ESCC) surgery after neoadjuvant chemotherapy (NAC) and to verify its significance in an independent validation cohort from another hospital.

Authors

  • Keita Kouzu
    Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Hironori Tsujimoto
    Department of Surgery, National Defense Medical College, Tokorozawa, Japan.
  • Yu Imamura
    Department of Esophageal Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  • Yoshiki Kajiwara
    Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Ines P Nearchou
    School of Medicine, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9TF, UK.
  • Takahiro Einama
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
  • Manabu Takamatsu
    Division of Pathology, The Cancer Institute; Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan. Electronic address: manabu.takamatsu@jfcr.or.jp.
  • Ikumi Haraguchi
    Cancer Precision Medicine Center, Cancer Institute of Japanese Foundation for Cancer Research, Koto, Tokyo, Japan.
  • Takanori Watanabe
    Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
  • Hiroyuki Horiguchi
    Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
  • Yoji Kishi
    Department of Surgery, National Defense Medical College, Saitama, Japan.
  • Hitoshi Tsuda
    Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
  • Masayuki Watanabe
  • Hideki Ueno
    Department of Surgery, National Defense Medical College, Saitama, Japan.