Aberrant patterns of spontaneous brain activity in schizophrenia: A resting-state fMRI study and classification analysis.

Journal: Progress in neuro-psychopharmacology & biological psychiatry
Published Date: Jun 18, 2024

Abstract

BACKGROUND: Schizophrenia is a prevalent mental disorder, leading to severe disability. Currently, the absence of objective biomarkers hinders effective diagnosis. This study was conducted to explore the aberrant spontaneous brain activity and investigate the potential of abnormal brain indices as diagnostic biomarkers employing machine learning methods.

Authors

  • Rong Zhang
    Internal Medicine - Cardiology Division, UT Southwestern, Dallas, TX, USA.
  • Juanjuan Ren
    Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Xiaoxia Lei
    Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Yewei Wang
    Department of Radiation Physics, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
  • Xiaochang Chen
    Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Lirong Fu
    Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Qingyi Li
    Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Chaoyue Guo
    Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Xinyue Teng
    Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Zenan Wu
    Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Lingfang Yu
    Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Dandan Wang
    Department of Traditional Chinese Medicine Orthopedics and Traumatology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Yan Chen
    Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Chen Zhang
    Department of Dermatology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Keywords

External Resources

Popular Topics
Recent Journals