MOSAIC: An Artificial Intelligence-Based Framework for Multimodal Analysis, Classification, and Personalized Prognostic Assessment in Rare Cancers.

Journal: JCO clinical cancer informatics
Published Date:

Abstract

PURPOSE: Rare cancers constitute over 20% of human neoplasms, often affecting patients with unmet medical needs. The development of effective classification and prognostication systems is crucial to improve the decision-making process and drive innovative treatment strategies. We have created and implemented MOSAIC, an artificial intelligence (AI)-based framework designed for multimodal analysis, classification, and personalized prognostic assessment in rare cancers. Clinical validation was performed on myelodysplastic syndrome (MDS), a rare hematologic cancer with clinical and genomic heterogeneities.

Authors

  • Saverio D'Amico
    IRCCS Istituto Clinico Humanitas, Milan, Italy.
  • Lorenzo Dall'Olio
    Department of Physics and Astronomy, University of Bologna, 40126, Bologna, BO, Italy.
  • Cesare Rollo
    Department of Medical Sciences, University of Turin, 10126, Turin, Italy.
  • Patricia Alonso
    Department of Signals, Systems and Radiocommunications, Polytechnic University of Madrid, Madrid, Spain.
  • Iñigo Prada-Luengo
    Department of Computer Science, University of Copenhagen, Copenhagen, Denmark.
  • Daniele Dall'Olio
    Department of Physics and Astronomy, University of Bologna, 40127 Bologna, Italy.
  • Claudia Sala
    Monoclonal Antibody Discovery Laboratory, Fondazione Toscana Life Sciences, Siena, Italy. c.sala@toscanalifesciences.org.
  • Elisabetta Sauta
    Humanitas Clinical and Research Center-IRCCS, Milan, Italy.
  • Gianluca Asti
    Humanitas Clinical and Research Center-IRCCS, Milan, Italy.
  • Luca Lanino
    Humanitas Clinical and Research Center-IRCCS, Milan, Italy.
  • Giulia Maggioni
    Humanitas Clinical and Research Center-IRCCS, Milan, Italy.
  • Alessia Campagna
    Humanitas Clinical and Research Center-IRCCS, Milan, Italy.
  • Elena Zazzetti
    Humanitas Clinical and Research Center-IRCCS, Milan, Italy.
  • Mattia Delleani
    Humanitas Clinical and Research Center-IRCCS, Milan, Italy.
  • Maria Elena Bicchieri
    Humanitas Clinical and Research Center-IRCCS, Milan, Italy.
  • Pierandrea Morandini
    Artificial Intelligence Center, Humanitas Clinical and Research Center-IRCCS, 20089 Milan, Italy.
  • Victor Savevski
    Artificial Intelligence Center IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Milan, Italy.
  • Borja Arroyo
    Department of Signals, Systems and Radiocommunications, Polytechnic University of Madrid, Madrid, Spain.
  • Juan Parras
    Information Processing and Telecommunications Center, E.T.S. Ingenieros de Telecomunicación, Universidad Politécnica de Madrid, 28040 Madrid, Spain.
  • Lin Pierre Zhao
    Hematology and Bone Marrow Transplantation, Hôpital Saint-Louis/University Paris 7, Paris, France.
  • Uwe Platzbecker
    Medical Clinic and Polyclinic I, University Hospital, Technical University Dresden, Dresden, Germany.
  • Maria Diez-Campelo
    Hematology Department, Hospital Universitario de Salamanca, Salamanca, Spain.
  • Valeria Santini
    AOU Careggi, University of Florence, Florence, Italy. Electronic address: valeria.santini@unifi.it.
  • Pierre Fenaux
    Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France.
  • Torsten Haferlach
    MLL Munich Leukemia Laboratory, Munich, Germany.
  • Anders Krogh
    Department of Computer Science, University of Copenhagen, Copenhagen, Denmark.
  • Santiago Zazo
    Information Processing and Telecommunications Center, E.T.S. Ingenieros de Telecomunicación, Universidad Politécnica de Madrid, 28040 Madrid, Spain.
  • Piero Fariselli
  • Tiziana Sanavia
    Department of Medical Science, University of Turin, Via Santena 19, 10126 Torino, Italy.
  • Matteo Giovanni Della Porta
    Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Gastone Castellani
    Department of Specialised, Diagnostic and Experimental Medicine, University of Bologna, 40126, Bologna, BO, Italy.