Identification of ion channel-related genes as diagnostic markers and potential therapeutic targets for osteoarthritis through bioinformatics and machine learning-based approaches.

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
PMID: 38767974

Abstract

BACKGROUND: Osteoarthritis (OA) is a debilitating joint disorder characterized by the progressive degeneration of articular cartilage. Although the role of ion channels in OA pathogenesis is increasingly recognized, diagnostic markers and targeted therapies remain limited.

Authors

  • Liu Yongming
    Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Xiong Yizhe
    Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Qian Zhikai
    Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
  • Wang Yupeng
    Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Wang Xiang
    Hunan Key Laboratory of Smart Roadway and Cooperative Vehicle-Infrastructure Systems(No.2017TP1016), Changsha University of Science and Technology, Changsha, Hunan, China.
  • Yin Mengyuan
    Department of Traditional Chinese Orthopedics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
  • Du Guoqing
    Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Zhan Hongsheng
    Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

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