Threshold of Dopamine D2/3 Receptor Occupancy for Hyperprolactinemia in Older Patients With Schizophrenia.

Journal: The Journal of clinical psychiatry
PMID: 28086010

Abstract

OBJECTIVE: Although hyperprolactinemia carries a long-term risk of morbidity, the threshold of dopamine D2/3 receptor (D2/3R) occupancy for hyperprolactinemia has not been investigated in older patients with schizophrenia. Data were taken from a positron emission tomography (PET) study conducted between August 2007 and August 2015. The present post hoc study included 42 clinically stable outpatients with schizophrenia (DSM-IV) (mean ± SD age = 60.2 ± 6.7 years) taking olanzapine or risperidone. Subjects underwent [¹¹C]-raclopride PET scans to measure D2/3R occupancy before and after reducing their dose of antipsychotic by up to 40%. Blood samples were collected before each PET scan to measure prolactin levels.

Authors

  • Yusuke Iwata
    Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada.
  • Shinichiro Nakajima
    Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada.
  • Fernando Caravaggio
    Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada.
  • Takefumi Suzuki
    Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan.
  • Hiroyuki Uchida
    Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan.
  • Eric Plitman
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
  • Jun Ku Chung
    Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada.
  • Wanna Mar
    Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada.
  • Philip Gerretsen
    Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada.
  • Bruce G Pollock
    Department of Psychiatry, University of Toronto, Toronto, Canada.
  • Benoit H Mulsant
    Department of Psychiatry, University of Toronto, Toronto, Canada.
  • Tarek K Rajji
    Department of Psychiatry, University of Toronto, Toronto, Canada.
  • David C Mamo
    Department of Psychiatry, Faculties of Medicine and Health Science, University of Malta, Msida.
  • Ariel Graff-Guerrero
    Geriatric Mental Health Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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