AIMC Topic: Benzodiazepines

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Network models incorporating chloride dynamics predict optimal strategies for terminating status epilepticus.

Neurobiology of disease
Status epilepticus (SE), seizures lasting beyond five minutes, is a medical emergency commonly treated with benzodiazepines which enhance GABA receptor (GABAR) conductance. Despite widespread use, benzodiazepines fail in over one-third of patients, p...

Prediction of remission of pharmacologically treated psychotic depression: A machine learning approach.

Journal of affective disorders
BACKGROUND: The combination of antidepressant and antipsychotic medication is an effective treatment for major depressive disorder with psychotic features ('psychotic depression'). The present study aims to identify sociodemographic and clinical pred...

Predicting remission after acute phase pharmacotherapy in patients with bipolar I depression: A machine learning approach with cross-trial and cross-drug replication.

Bipolar disorders
OBJECTIVES: Interpatient variability in bipolar I depression (BP-D) symptoms challenges the ability to predict pharmacotherapeutic outcomes. A machine learning workflow was developed to predict remission after 8 weeks of pharmacotherapy (total score ...

Clinical decision-making in benzodiazepine deprescribing by healthcare providers vs. AI-assisted approach.

British journal of clinical pharmacology
AIMS: The aim of this study was to compare the clinical decision-making for benzodiazepine deprescribing between a healthcare provider (HCP) and an artificial intelligence (AI) chatbot GPT4 (ChatGPT-4).

How prevalent and severe is addiction on GABAmimetic drugs in an elderly German general hospital population? Focus on gabapentinoids, benzodiazepines, and z-hypnotic drugs.

Human psychopharmacology
OBJECTIVE: Gabapentinoids (GPT) are reported to be increasingly misused by opioid- and polydrug-users, but the addictive potential of GPT outside of these populations remains understudied. Investigations comparing GPT abuse and dependence liability t...

A case of fatal multidrug intoxication involving flualprazolam: distribution in body fluids and solid tissues.

Forensic toxicology
PURPOSE: Designer benzodiazepines (DBZDs) increasingly emerged on the novel psychoactive substance (NPS) market in the last few years. They are usually sold as readily available alternatives to prescription benzodiazepines (BZDs) or added to counterf...

Field-Portable Technology for Illicit Drug Discrimination via Deep Learning of Hybridized Reflectance/Fluorescence Spectroscopic Fingerprints.

Analytical chemistry
Novel psychoactive substances (NPS) pose one of the greatest challenges across the illicit drug landscape. They can be highly potent, and coupled with rapid changes in structure, tracking and identifying these drugs is difficult and presents users wi...

Threshold of Dopamine D2/3 Receptor Occupancy for Hyperprolactinemia in Older Patients With Schizophrenia.

The Journal of clinical psychiatry
OBJECTIVE: Although hyperprolactinemia carries a long-term risk of morbidity, the threshold of dopamine D2/3 receptor (D2/3R) occupancy for hyperprolactinemia has not been investigated in older patients with schizophrenia. Data were taken from a posi...