Machine learning uncovers manganese as a key nutrient associated with reduced risk of steatotic liver disease.

Journal: Liver international : official journal of the International Association for the Study of the Liver
PMID:

Abstract

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 20%-30% of the general population and is linked to high-caloric western style diet. However, there are little data that specific nutrients might help to prevent steatosis.

Authors

  • Simon Schophaus
    Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
  • Kate Townsend Creasy
    Cardiovascular Research Institute, Department of Medicine University of California San Francisco, USA.
  • Paul-Henry Koop
    Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
  • Jan Clusmann
    Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
  • Julius Jaeger
    Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
  • Varnitha Punnuru
    Department of Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Alexander Koch
    Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
  • Christian Trautwein
    Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
  • Rohit Loomba
    From the Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering (A.H., W.D.O.), and Department of Food Science and Human Nutrition (J.W.E.), University of Illinois at Urbana-Champaign, 306 N Wright St, Urbana, IL 61801; Department of Radiology (M.B., M.P.A.), Liver Imaging Group, Department of Radiology (E.H., C.B.S.), and NAFLD Research Center, Division of Gastroenterology, Department of Medicine (R.L.), University of California, San Diego, La Jolla, Calif; and Department of Ultrasound, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland (M.B.).
  • Tom Luedde
    Division of Gastroenterology, Hepatology and Hepatobiliary Oncology, University Hospital RWTH Aachen, Aachen, Germany.
  • Kai Markus Schneider
    Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
  • Carolin V Schneider
    Department of Internal Medicine III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.