Cold Spring Harbor perspectives in biology
Jun 2, 2025
Neural development must construct neural circuits that can perform the computations necessary for survival. However, many theoretical models of development do not explicitly address the computational goals of the resulting networks, or computations t...
Cold Spring Harbor perspectives in biology
Sep 3, 2024
From over to , the recent decade of exponential advances in artificial intelligence (AI) has been altering life. In parallel, advances in computational biology are beginning to decode the language of life: leaped forward in protein structure predi...
Cold Spring Harbor perspectives in biology
Jul 1, 2024
Over the years, many computational methods have been created for the analysis of the impact of single amino acid substitutions resulting from single-nucleotide variants in genome coding regions. Historically, all methods have been supervised and thus...
Cold Spring Harbor perspectives in biology
Mar 1, 2024
Antibodies are versatile proteins with both the capacity to bind a broad range of targets and a proven track record as some of the most successful therapeutics. However, the development of novel antibody therapeutics is a lengthy and costly process. ...
Cold Spring Harbor perspectives in biology
Feb 1, 2024
Machine learning-based design has gained traction in the sciences, most notably in the design of small molecules, materials, and proteins, with societal applications ranging from drug development and plastic degradation to carbon sequestration. When ...
Cold Spring Harbor perspectives in biology
Dec 1, 2023
Computing tools and machine learning models play an increasingly important role in biology and are now an essential part of discoveries in protein science. The growing energy needs of modern algorithms have raised concerns in the computational scienc...
Cold Spring Harbor perspectives in biology
Apr 1, 2016
The restriction of adult neurogenesis to only a handful of regions of the brain is suggestive of some shared requirement for this dramatic form of structural plasticity. However, a common driver across neurogenic regions has not yet been identified. ...