AIMC Topic: Adverse Drug Reaction Reporting Systems

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Facilitating prediction of adverse drug reactions by using knowledge graphs and multi-label learning models.

Briefings in bioinformatics
Timely identification of adverse drug reactions (ADRs) is highly important in the domains of public health and pharmacology. Early discovery of potential ADRs can limit their effect on patient lives and also make drug development pipelines more robus...

Adverse Drug Events Detection in Clinical Notes by Jointly Modeling Entities and Relations Using Neural Networks.

Drug safety
BACKGROUND AND SIGNIFICANCE: Adverse drug events (ADEs) occur in approximately 2-5% of hospitalized patients, often resulting in poor outcomes or even death. Extraction of ADEs from clinical narratives can accelerate and automate pharmacovigilance. U...

Detecting Adverse Drug Events with Rapidly Trained Classification Models.

Drug safety
INTRODUCTION: Identifying occurrences of medication side effects and adverse drug events (ADEs) is an important and challenging task because they are frequently only mentioned in clinical narrative and are not formally reported.

A chronological pharmacovigilance network analytics approach for predicting adverse drug events.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVES: This study extends prior research by combining a chronological pharmacovigilance network approach with machine-learning (ML) techniques to predict adverse drug events (ADEs) based on the drugs' similarities in terms of the proteins they t...

Natural Language Processing for EHR-Based Pharmacovigilance: A Structured Review.

Drug safety
The goal of pharmacovigilance is to detect, monitor, characterize and prevent adverse drug events (ADEs) with pharmaceutical products. This article is a comprehensive structured review of recent advances in applying natural language processing (NLP) ...

Development of an automated assessment tool for MedWatch reports in the FDA adverse event reporting system.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: As the US Food and Drug Administration (FDA) receives over a million adverse event reports associated with medication use every year, a system is needed to aid FDA safety evaluators in identifying reports most likely to demonstrate causal ...

Adverse Drug Event Monitoring with Clinical and Laboratory Data Using Arden Syntax.

Studies in health technology and informatics
In times of steadily increasing numbers of administered drugs, the detection of adverse drug events (ADEs) is an important aspect of improving patient safety. At present only about 1-13% of detected ADEs are reported. Raising the number of reported A...

Exploring brand-name drug mentions on Twitter for pharmacovigilance.

Studies in health technology and informatics
Twitter has been proposed by several studies as a means to track public health trends such as influenza and Ebola outbreaks by analyzing user messages in order to measure different population features and interests. In this work we analyze the number...