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Alkanes

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An automated high-throughput SPE micro-elution method for perfluoroalkyl substances in human serum.

Analytical and bioanalytical chemistry
An automated high-throughput solid phase extraction (SPE) micro-elution method for 8 perfluorosulfonic acids, 11 perfluorocarboxylic acids and fluorooctane sulfonamide in human serum was developed. Importance was attached to the application of small ...

Machine learning of single molecule free energy surfaces and the impact of chemistry and environment upon structure and dynamics.

The Journal of chemical physics
The conformational states explored by polymers and proteins can be controlled by environmental conditions (e.g., temperature, pressure, and solvent) and molecular chemistry (e.g., molecular weight and side chain identity). We introduce an approach em...

Predicting Thermodynamic Properties of Alkanes by High-Throughput Force Field Simulation and Machine Learning.

Journal of chemical information and modeling
Knowledge of the thermodynamic properties of molecules is essential for chemical process design and the development of new materials. Experimental measurements are often expensive and not environmentally friendly. In the past, studies using molecular...

Efficient Exploration of Chemical Compound Space Using Active Learning for Prediction of Thermodynamic Properties of Alkane Molecules.

Journal of chemical information and modeling
We introduce an exploratory active learning (AL) algorithm using Gaussian process regression and marginalized graph kernel (GPR-MGK) to sample chemical compound space (CCS) at minimal cost. Targeting 251,728 enumerated alkane molecules with 4-19 carb...