AIMC Topic: Aplysia

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AI protein structure prediction-based modeling and mutagenesis of a protostome receptor and peptide ligands reveal key residues for their interaction.

The Journal of biological chemistry Aug 30, 2022
The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-coupled receptors, has been characterized in several species. Despite the progress, molecular mechanisms governing LK peptide-receptor interactions remain to b...
Artificial Intelligence Animals Receptors, Neuropeptide Amides Ligands Protein Conformation Mutagenesis Neuropeptides Aplysia
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Image-guided MALDI mass spectrometry for high-throughput single-organelle characterization.

Nature methods Sep 30, 2021
Peptidergic dense-core vesicles are involved in packaging and releasing neuropeptides and peptide hormones-critical processes underlying brain, endocrine and exocrine function. Yet, the heterogeneity within these organelles, even for morphologically ...
Machine Learning Animals Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization High-Throughput Screening Assays Organelles Aplysia
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Neuromorphic learning with Mott insulator NiO.

Proceedings of the National Academy of Sciences of the United States of America Sep 28, 2021
Habituation and sensitization (nonassociative learning) are among the most fundamental forms of learning and memory behavior present in organisms that enable adaptation and learning in dynamic environments. Emulating such features of intelligence fou...
Neural Networks, Computer Artificial Intelligence Algorithms Animals Neuronal Plasticity Models, Neurological Nickel Electrons Synapses Insulator Elements Aplysia
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