AIMC Topic: Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Rapid detection of antibiotic resistance in Burkholderia pseudomallei using MALDI-TOF mass spectrometry.
Scientific reports
Jul 1, 2025
Antibiotic resistance in Burkholderia pseudomallei (Bp) is a growing public health concern requiring urgent attention. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has emerged as a rapid bacterial identi...
A lipid atlas of the human kidney.
Science advances
Jun 11, 2025
Tissue atlases provide foundational knowledge on the cellular organization and molecular distributions across molecular classes and spatial scales. Here, we construct a comprehensive spatiomolecular lipid atlas of the human kidney from 29 donor tissu...
Constructing Built-In Electric Field in Hierarchical-Flower Heterostructure for High-Performance Serum Metabolic Assay.
Analytical chemistry
May 20, 2025
Laser desorption ionization mass spectrometry (LDI-MS) is a critical platform for high-throughput nontargeted metabolomics analysis in clinical diagnosis. However, traditional organic matrices inherently suffer from background interference in the low...
MALDI-TOF mass spectrometry combined with machine learning algorithms to identify protein profiles related to malaria infection in human sera from Côte d'Ivoire.
Malaria journal
Apr 18, 2025
BACKGROUND: In sub-Saharan Africa, Plasmodium falciparum is the most prevalent species of malaria parasites. In endemic areas, malaria is mainly diagnosed using microscopy or rapid diagnostic tests (RDTs), which have limited sensitivity, and microsco...
AI-driven framework to map the brain metabolome in three dimensions.
Nature metabolism
Mar 18, 2025
High-resolution spatial imaging is transforming our understanding of foundational biology. Spatial metabolomics is an emerging field that enables the dissection of the complex metabolic landscape and heterogeneity from a thin tissue section. Currentl...
Enhanced authentication of organic milk using MALDI-TOF MS with combined lipid-peptide fingerprinting and machine learning integration.
Food chemistry
Feb 10, 2025
This study introduces a method for authenticating organic milk and determining its geographic region using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Both lipids and peptides were analyzed, and their ...
Energy-Confinement 3D Flower-Shaped Cages for AI-Driven Decoding of Metabolic Fingerprints in Cardiovascular Disease Diagnosis.
ACS nano
Feb 7, 2025
Rapid and accurate detection plays a critical role in improving the survival and prognosis of patients with cardiovascular disease, but traditional detection methods are far from ideal for those with suspected conditions. Metabolite analysis based on...
End-To-End Deep Learning Explains Antimicrobial Resistance in Peak-Picking-Free MALDI-MS Data.
Analytical chemistry
Feb 2, 2025
Mass spectrometry is used to determine infectious microbial species in thousands of clinical laboratories across the world. The vast amount of data allows modern data analysis methods that harvest more information and potentially answer new questions...
Integrating Machine Learning with MALDI-TOF Mass Spectrometry for Rapid and Accurate Antimicrobial Resistance Detection in Clinical Pathogens.
International journal of molecular sciences
Jan 28, 2025
Antimicrobial resistance (AMR) is one of the most pressing public health challenges of the 21st century. This study aims to evaluate the efficacy of mass spectral data generated by VITEK MS instruments for predicting antibiotic resistance in , , and ...
Rapid detection of carbapenem-resistant Escherichia coli and carbapenem-resistant Klebsiella pneumoniae in positive blood cultures via MALDI-TOF MS and tree-based machine learning models.
BMC microbiology
Jan 24, 2025
BACKGROUND: Bloodstream infection (BSI) is a systemic infection that predisposes individuals to sepsis and multiple organ dysfunction syndrome. Early identification of infectious agents and determination of drug-resistant phenotypes can help patients...
Bacteremia
Blood Culture
Klebsiella Infections
Anti-Bacterial Agents
Microbial Sensitivity Tests
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Escherichia coli
Klebsiella pneumoniae
Humans
Carbapenems
Decision Trees
Machine Learning
Carbapenem-Resistant Enterobacteriaceae
Escherichia coli Infections
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