AIMC Topic: Receptors, Neuropeptide

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Molecular insights into the unique activation and allosteric modulation mechanisms of the human mas-related G-protein-coupled receptor X1.

International journal of biological macromolecules May 30, 2025
MRGPRX1 plays dual roles in mediating nociception and pruritus, making it a promising target for alleviating itch and inhibiting pain. However, the mechanisms underlying MRGPRX1 activation and allosteric modulation remain poorly understood, posing si...
Humans Protein Binding Receptors, Neuropeptide Receptors, G-Protein-Coupled Molecular Dynamics Simulation Protein Conformation Binding Sites Allosteric Regulation
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Functional MRGPRX2 expression on peripheral blood-derived human mast cells increases at low seeding density and is suppressed by interleukin-9 and fetal bovine serum.

Frontiers in immunology Dec 13, 2024
Primary human mast cells (MC) obtained through culturing of blood-derived MC progenitors are the preferred model for the study of MRGPRX2- IgE-mediated MC activation. In order to assess the impact of culture conditions on functional MRGPRX2 express...
Humans Cells, Cultured Animals Cattle Interleukin-9 Mast Cells Receptors, Neuropeptide Nerve Tissue Proteins Receptors, G-Protein-Coupled
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AI protein structure prediction-based modeling and mutagenesis of a protostome receptor and peptide ligands reveal key residues for their interaction.

The Journal of biological chemistry Aug 30, 2022
The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-coupled receptors, has been characterized in several species. Despite the progress, molecular mechanisms governing LK peptide-receptor interactions remain to b...
Artificial Intelligence Animals Receptors, Neuropeptide Amides Ligands Protein Conformation Mutagenesis Neuropeptides Aplysia
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