AIMC Topic: Receptors, Neuropeptide

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Design, Synthesis, and Aphicidal Activity of Novel Insect Neuropeptide Kinin Receptor Antagonists, Targeting the Ser Ligand Position.

Journal of agricultural and food chemistry Sep 26, 2025
Traditional chemical pesticides have raised significant environmental and health concerns, driving the pursuit of safer alternatives. Aphids, notorious for causing extensive agricultural damage and transmitting plant diseases, represent prime targets...
Animals Molecular Docking Simulation Drug Design Receptors, Neuropeptide Insecticides Ligands Quantitative Structure-Activity Relationship Insect Proteins Neuropeptides Aphids Kinins
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Molecular insights into the unique activation and allosteric modulation mechanisms of the human mas-related G-protein-coupled receptor X1.

International journal of biological macromolecules May 30, 2025
MRGPRX1 plays dual roles in mediating nociception and pruritus, making it a promising target for alleviating itch and inhibiting pain. However, the mechanisms underlying MRGPRX1 activation and allosteric modulation remain poorly understood, posing si...
Humans Protein Binding Receptors, Neuropeptide Receptors, G-Protein-Coupled Molecular Dynamics Simulation Protein Conformation Binding Sites Allosteric Regulation
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Functional MRGPRX2 expression on peripheral blood-derived human mast cells increases at low seeding density and is suppressed by interleukin-9 and fetal bovine serum.

Frontiers in immunology Dec 13, 2024
Primary human mast cells (MC) obtained through culturing of blood-derived MC progenitors are the preferred model for the study of MRGPRX2- IgE-mediated MC activation. In order to assess the impact of culture conditions on functional MRGPRX2 express...
Humans Cells, Cultured Animals Cattle Interleukin-9 Mast Cells Receptors, Neuropeptide Nerve Tissue Proteins Receptors, G-Protein-Coupled
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AI protein structure prediction-based modeling and mutagenesis of a protostome receptor and peptide ligands reveal key residues for their interaction.

The Journal of biological chemistry Aug 30, 2022
The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-coupled receptors, has been characterized in several species. Despite the progress, molecular mechanisms governing LK peptide-receptor interactions remain to b...
Artificial Intelligence Animals Receptors, Neuropeptide Amides Ligands Protein Conformation Mutagenesis Neuropeptides Aplysia
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