AIMC Topic: Chaperonin 60

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Disruption of Hsp70.14-BAG2 Protein-Protein interactions using deep Learning-Driven peptide design and molecular simulations.

Computers in biology and medicine Jun 3, 2025
Protein-protein interactions (PPIS) are critical in proteostasis, stress response, and disease progression. Targeting the interaction between Hsp70.14 and BAG2, a co-chaperone implicated in oncogenic survival, offers a promising therapeutic approach....
Humans Molecular Docking Simulation Deep Learning Protein Binding Molecular Dynamics Simulation HSP70 Heat-Shock Proteins Molecular Chaperones Antimicrobial Peptides Mitochondrial Proteins Chaperonin 60
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Swallowing a Surgeon: Toward Clinical Nanorobots.

Accounts of chemical research Mar 21, 2017
In this Account, "a step toward clinical nanorobots" is proposed as one of the Holy Grails in chemistry, which could lead to a great leap in the field of biomedicines when accomplished. We review our preliminary contributions to this challenge by eng...
Humans Robotics Robotic Surgical Procedures Nanotechnology Nanocapsules Deglutition Chaperonin 60
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