AIMC Topic: Chromosome Segregation

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High-throughput classification of S. cerevisiae tetrads using deep learning.

Yeast (Chichester, England) Jun 8, 2024
Meiotic crossovers play a vital role in proper chromosome segregation and evolution of most sexually reproducing organisms. Meiotic recombination can be visually observed in Saccharomyces cerevisiae tetrads using linked spore-autonomous fluorescent m...
Deep Learning Image Processing, Computer-Assisted High-Throughput Screening Assays Saccharomyces cerevisiae Meiosis Chromosome Segregation Crossing Over, Genetic
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Machine learning classification of trajectories from molecular dynamics simulations of chromosome segregation.

PloS one Jan 21, 2022
In contrast to the well characterized mitotic machinery in eukaryotes it seems as if there is no universal mechanism organizing chromosome segregation in all bacteria. Apparently, some bacteria even use combinations of different segregation mechanism...
Machine Learning Bacteria Microscopy, Fluorescence Molecular Dynamics Simulation DNA Replication Chromosome Segregation
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Computed structures of core eukaryotic protein complexes.

Science (New York, N.Y.) Dec 10, 2021
Protein-protein interactions play critical roles in biology, but the structures of many eukaryotic protein complexes are unknown, and there are likely many interactions not yet identified. We take advantage of advances in proteome-wide amino acid coe...
Computer Simulation Deep Learning Protein Interaction Maps Computational Biology Proteome Membrane Proteins Evolution, Molecular Models, Molecular Protein Conformation Saccharomyces cerevisiae Ubiquitin Protein Interaction Mapping Saccharomyces cerevisiae Proteins DNA Repair Protein Biosynthesis Ribosomes Multiprotein Complexes Acyltransferases Homologous Recombination Chromosome Segregation Ligases
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DeepTetrad: high-throughput image analysis of meiotic tetrads by deep learning in Arabidopsis thaliana.

The Plant journal : for cell and molecular biology Oct 22, 2019
Meiotic crossovers facilitate chromosome segregation and create new combinations of alleles in gametes. Crossover frequency varies along chromosomes and crossover interference limits the coincidence of closely spaced crossovers. Crossovers can be mea...
Deep Learning Alleles Transgenes Meiosis Arabidopsis Proteins Arabidopsis Pollen Homologous Recombination Chromosome Segregation Chromosomes, Plant Crossing Over, Genetic
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