AIMC Topic: Acyltransferases

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Palmitoylation-related gene ZDHHC22 as a potential diagnostic and immunomodulatory target in Alzheimer's disease: insights from machine learning analyses and WGCNA.

European journal of medical research Jan 22, 2025
BACKGROUND: The mechanism of palmitoylation in the pathogenesis of Alzheimer's disease (AD) remains unclear.
ROC Curve Gene Regulatory Networks Machine Learning Acyltransferases Alzheimer Disease Lipoylation Humans
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Computed structures of core eukaryotic protein complexes.

Science (New York, N.Y.) Dec 10, 2021
Protein-protein interactions play critical roles in biology, but the structures of many eukaryotic protein complexes are unknown, and there are likely many interactions not yet identified. We take advantage of advances in proteome-wide amino acid coe...
Homologous Recombination Chromosome Segregation Ligases Multiprotein Complexes Acyltransferases Ribosomes Computational Biology Proteome Membrane Proteins Evolution, Molecular Deep Learning Protein Interaction Maps Computer Simulation Saccharomyces cerevisiae Protein Interaction Mapping Models, Molecular Ubiquitin Saccharomyces cerevisiae Proteins Protein Conformation DNA Repair Protein Biosynthesis
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Deep Learning Reveals Liver MRI Features Associated With PNPLA3 I148M in Steatotic Liver Disease.

Liver international : official journal of the International Association for the Study of the Liver Jul 1, 2025
BACKGROUND: Steatotic liver disease (SLD) is the most common liver disease worldwide, affecting 30% of the global population. It is strongly associated with the interplay of genetic and lifestyle-related risk factors. The genetic variant accounting f...
Humans Magnetic Resonance Imaging Liver Fatty Liver Membrane Proteins Acyltransferases Phospholipases A2, Calcium-Independent Male Non-alcoholic Fatty Liver Disease Deep Learning Middle Aged Aged Lipase Genetic Predisposition to Disease Female Adult
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Integrated machine learning, molecular docking and 3D-QSAR based approach for identification of potential inhibitors of trypanosomal N-myristoyltransferase.

Molecular bioSystems Nov 15, 2016
N-Myristoyltransferase (NMT) catalyzes the transfer of myristate to the amino-terminal glycine of a subset of proteins, a co-translational modification involved in trafficking substrate proteins to membrane locations, stabilization and protein-protei...
Catalytic Domain Protein Binding Trypanocidal Agents Parasitic Sensitivity Tests Workflow Molecular Dynamics Simulation Datasets as Topic Acyltransferases Algorithms Machine Learning Quantitative Structure-Activity Relationship Enzyme Inhibitors Molecular Docking Simulation Binding Sites
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