Acyltransferases

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Palmitoylation-related gene ZDHHC22 as a potential diagnostic and immunomodulatory target in Alzheimer's disease: insights from machine learning analyses and WGCNA.

European journal of medical research Jan 22, 2025
BACKGROUND: The mechanism of palmitoylation in the pathogenesis of Alzheimer's disease (AD) remains unclear.
ROC Curve Gene Regulatory Networks Machine Learning Acyltransferases Alzheimer Disease Lipoylation Humans
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Computed structures of core eukaryotic protein complexes.

Science (New York, N.Y.) Dec 10, 2021
Protein-protein interactions play critical roles in biology, but the structures of many eukaryotic protein complexes are unknown, and there are likely many interactions not yet identified. We take advantage of advances in proteome-wide amino acid coe...
Homologous Recombination Chromosome Segregation Ligases Multiprotein Complexes Acyltransferases Ribosomes Computational Biology Proteome Membrane Proteins Evolution, Molecular Protein Interaction Mapping Deep Learning Saccharomyces cerevisiae Proteins Protein Interaction Maps Saccharomyces cerevisiae DNA Repair Computer Simulation Ubiquitin Models, Molecular Protein Biosynthesis Protein Conformation
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Deep Learning Reveals Liver MRI Features Associated With PNPLA3 I148M in Steatotic Liver Disease.

Liver international : official journal of the International Association for the Study of the Liver Jul 1, 2025
BACKGROUND: Steatotic liver disease (SLD) is the most common liver disease worldwide, affecting 30% of the global population. It is strongly associated with the interplay of genetic and lifestyle-related risk factors. The genetic variant accounting f...
Humans Magnetic Resonance Imaging Liver Male Aged Middle Aged Adult Fatty Liver Female Acyltransferases Membrane Proteins Deep Learning Phospholipases A2, Calcium-Independent Genetic Predisposition to Disease Non-alcoholic Fatty Liver Disease Lipase
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Integrated machine learning, molecular docking and 3D-QSAR based approach for identification of potential inhibitors of trypanosomal N-myristoyltransferase.

Molecular bioSystems Nov 15, 2016
N-Myristoyltransferase (NMT) catalyzes the transfer of myristate to the amino-terminal glycine of a subset of proteins, a co-translational modification involved in trafficking substrate proteins to membrane locations, stabilization and protein-protei...
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Catalytic Domain Parasitic Sensitivity Tests Trypanocidal Agents Protein Binding Algorithms Machine Learning Quantitative Structure-Activity Relationship Acyltransferases Molecular Dynamics Simulation Workflow Datasets as Topic Molecular Docking Simulation Binding Sites Enzyme Inhibitors
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