AIMC Topic: Ligases

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Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.

Nature communications Jun 18, 2025
Bio-instructive materials that intrinsically inhibit biofilm formation have significant anti-biofouling potential in industrial and healthcare settings. Since bacterial surface attachment is sensitive to surface topography, we experimentally surveyed...
Female Animals Biofilms Mice Transcription Factors Bacterial Proteins Polymers Pseudomonas aeruginosa Bacterial Adhesion Surface Properties Quorum Sensing Glycolipids 4-Butyrolactone Pseudomonas Infections Biofouling Ligases
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Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL.

Angewandte Chemie (International ed. in English) Apr 27, 2023
Lanthipeptides are ribosomally-synthesized natural products from bacteria featuring stable thioether-crosslinks and various bioactivities. Herein, we report on a new clade of tricyclic class-IV lanthipeptides with curvocidin from Thermomonospora curv...
Artificial Intelligence Peptides Ligases
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Deep learning enabled multi-organ segmentation of mouse embryos.

Biology open Feb 21, 2023
The International Mouse Phenotyping Consortium (IMPC) has generated a large repository of three-dimensional (3D) imaging data from mouse embryos, providing a rich resource for investigating phenotype/genotype interactions. While the data is freely av...
Animals Deep Learning Mice Embryo, Mammalian Ligases Polycomb-Group Proteins
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Computed structures of core eukaryotic protein complexes.

Science (New York, N.Y.) Dec 10, 2021
Protein-protein interactions play critical roles in biology, but the structures of many eukaryotic protein complexes are unknown, and there are likely many interactions not yet identified. We take advantage of advances in proteome-wide amino acid coe...
Computer Simulation Deep Learning Protein Interaction Maps Computational Biology Proteome Membrane Proteins Evolution, Molecular Models, Molecular Protein Conformation Saccharomyces cerevisiae Ubiquitin Protein Interaction Mapping Saccharomyces cerevisiae Proteins DNA Repair Protein Biosynthesis Ribosomes Multiprotein Complexes Acyltransferases Homologous Recombination Chromosome Segregation Ligases
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