IEEE/ACM transactions on computational biology and bioinformatics
Oct 9, 2024
Accurate molecular representation plays a crucial role in expediting the process of drug discovery. Graph neural networks (GNNs) have demonstrated robust capabilities in molecular representation learning, adept at capturing structural and spatial inf...
IEEE/ACM transactions on computational biology and bioinformatics
Oct 9, 2024
DNA damage is a critical factor in the onset and progression of cancer. When DNA is damaged, the number of genetic mutations increases, making it necessary to activate DNA repair mechanisms. A crucial factor in the base excision repair process, which...
IEEE/ACM transactions on computational biology and bioinformatics
Oct 9, 2024
As medical safety and drug regulation gain heightened attention, the detection of spurious drug-drug interactions (DDI) has become key in healthcare. Although current research using graph neural networks (GNNs) to predict DDI has shown impressive res...
IEEE/ACM transactions on computational biology and bioinformatics
Oct 9, 2024
Pseudouridine is a type of abundant RNA modification that is seen in many different animals and is crucial for a variety of biological functions. Accurately identifying pseudouridine sites within the RNA sequence is vital for the subsequent study of ...
IEEE/ACM transactions on computational biology and bioinformatics
Oct 9, 2024
N4-acetylcytidine (ac4C) is a post-transcriptional modification in mRNA that is critical in mRNA translation in terms of stability and regulation. In the past few years, numerous approaches employing convolutional neural networks (CNN) and Transforme...
IEEE/ACM transactions on computational biology and bioinformatics
Oct 9, 2024
Viruses pose a great threat to human production and life, thus the research and development of antiviral drugs is urgently needed. Antiviral peptides play an important role in drug design and development. Compared with the time-consuming and laboriou...
IEEE/ACM transactions on computational biology and bioinformatics
Oct 9, 2024
COVID-19, caused by the highly contagious SARS-CoV-2 virus, is distinguished by its positive-sense, single-stranded RNA genome. A thorough understanding of SARS-CoV-2 pathogenesis is crucial for halting its proliferation. Notably, the 3C-like proteas...
IEEE/ACM transactions on computational biology and bioinformatics
Oct 9, 2024
Seasonal influenza vaccines play a crucial role in saving numerous lives annually. However, the constant evolution of the influenza A virus necessitates frequent vaccine updates to ensure its ongoing effectiveness. The decision to develop a new vacci...
IEEE/ACM transactions on computational biology and bioinformatics
Oct 9, 2024
Assigning appropriate rhetorical roles, such as "background," "intervention," and "outcome," to sentences in biomedical documents can streamline the process for physicians to locate evidence and resources for medical treatment and decision-making. Wh...
IEEE/ACM transactions on computational biology and bioinformatics
Oct 9, 2024
MicroRNAs (miRNA) are endogenous non-coding RNAs, typically around 23 nucleotides in length. Many miRNAs have been founded to play crucial roles in gene regulation though post-transcriptional repression in animals. Existing studies suggest that the d...