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Dicarboxylic Acids

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Large-Scale Screening of Natural Products Transactivating Peroxisome Proliferator-Activated Receptor α Identifies 9S-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid and Cymarin as Potential Compounds Capable of Increasing Apolipoprotein A-I Transcription in Human Liver Cells.

Lipids 30706477
Increasing apolipoprotein A-I (apoA-I), the predominant protein of high-density lipoprotein (HDL) particles, has favorable effects on atherogenic risk factors. Here, we investigated the effects of peroxisome proliferator-activated receptor α (PPARα) ...
Apolipoprotein A-I Biological Products Cell Survival Cymarine Dicarboxylic Acids HEK293 Cells Hep G2 Cells Humans PPAR alpha
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Editor's Highlight: Identification of Any Structure-Specific Hepatotoxic Potential of Different Pyrrolizidine Alkaloids Using Random Forests and Artificial Neural Networks.

Toxicological sciences : an official journal of the Society of Toxicology 28973379
Pyrrolizidine alkaloids (PAs) are characteristic metabolites of some plant families and form a powerful defense mechanism against herbivores. More than 600 different PAs are known. PAs are ester alkaloids composed of a necine base and a necic acid, w...
Algorithms Chemical and Drug Induced Liver Injury Cyclic N-Oxides Databases, Factual Dicarboxylic Acids Heterocyclic Compounds, 2-Ring Humans Liver Machine Learning Molecular Structure Neural Networks, Computer Pyrrolizidine Alkaloids Quantitative Structure-Activity Relationship Reproducibility of Results Risk Assessment
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