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Dihydrouracil Dehydrogenase (NADP)

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Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase.

Clinical pharmacology and therapeutics 29327356
Deleterious variants in dihydropyrimidine dehydrogenase (DPD, DPYD gene) can be highly predictive of clinical toxicity to the widely prescribed chemotherapeutic 5-fluorouracil (5-FU). However, there are very limited data pertaining to the functional ...
Antimetabolites, Antineoplastic Cell Survival Computer Simulation Dihydrouracil Dehydrogenase (NADP) Dose-Response Relationship, Drug Fluorouracil Gene Frequency Genotype HCT116 Cells HEK293 Cells Humans Inhibitory Concentration 50 Machine Learning Models, Molecular Mutation, Missense Pharmacogenetics Pharmacogenomic Testing Pharmacogenomic Variants Predictive Value of Tests Protein Conformation Risk Assessment Structure-Activity Relationship
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