AIMC Topic: Dihydrouracil Dehydrogenase (NADP)

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Gene-Specific Variant Classifier (DPYD-Varifier) to Identify Deleterious Alleles of Dihydropyrimidine Dehydrogenase.

Clinical pharmacology and therapeutics Feb 2, 2018
Deleterious variants in dihydropyrimidine dehydrogenase (DPD, DPYD gene) can be highly predictive of clinical toxicity to the widely prescribed chemotherapeutic 5-fluorouracil (5-FU). However, there are very limited data pertaining to the functional ...
Humans Machine Learning Computer Simulation Risk Assessment Pharmacogenetics Genotype Dose-Response Relationship, Drug Cell Survival Predictive Value of Tests Structure-Activity Relationship Models, Molecular Fluorouracil Inhibitory Concentration 50 HCT116 Cells HEK293 Cells Gene Frequency Protein Conformation Antimetabolites, Antineoplastic Mutation, Missense Dihydrouracil Dehydrogenase (NADP) Pharmacogenomic Testing Pharmacogenomic Variants
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