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Flap Endonucleases

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Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening.

Molecular bioSystems 28685785
Human Flap endonuclease1 (FEN1) is an enzyme that is indispensable for DNA replication and repair processes and inhibition of its Flap cleavage activity results in increased cellular sensitivity to DNA damaging agents (cisplatin, temozolomide, MMS, e...
Antineoplastic Agents Cell Line, Tumor Cell Survival Colon Databases, Chemical Drug Discovery Enzyme Inhibitors Epithelial Cells Flap Endonucleases Gene Expression HEK293 Cells Humans Inhibitory Concentration 50 Machine Learning Naphthoquinones Organ Specificity
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