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Biochimica et biophysica acta. Gene regulatory mechanisms
Jun 8, 2022
Transcription factors directly bind to DNA and regulate the expression of the gene, causing epigenetic modification of the DNA. They often mediate epigenetic parameters of transcriptional and posttranscriptional mechanisms, and their expression activ...
Genetics in medicine : official journal of the American College of Medical Genetics
May 25, 2022
Deep learning (DL) is applied in many biomedical areas. We performed a scoping review on DL in medical genetics. We first assessed 14,002 articles, of which 133 involved DL in medical genetics. DL in medical genetics increased rapidly during the stud...
Genome biology
May 17, 2022
BACKGROUND: Cancer is a set of diseases characterized by unchecked cell proliferation and invasion of surrounding tissues. The many genes that have been genetically associated with cancer or shown to directly contribute to oncogenesis vary widely bet...
Applied microbiology and biotechnology
May 12, 2022
Fungi produce several bioactive metabolites, pigments, dyes, antioxidants, polysaccharides, and industrial enzymes. Fungal products are also the primary sources of functional food and nutrition, and their pharmacological products are used for healthy...
NPJ systems biology and applications
Apr 29, 2022
Genomic profiles of cancer cells provide valuable information on genetic alterations in cancer. Several recent studies employed these data to predict the response of cancer cell lines to drug treatment. Nonetheless, due to the multifactorial phenotyp...
Genes
Apr 19, 2022
Cancer is a complex disease caused by genomic and epigenetic alterations; hence, identifying meaningful cancer drivers is an important and challenging task. Most studies have detected cancer drivers with mutated traits, while few studies consider mul...
BMC bioinformatics
Apr 9, 2022
BACKGROUND: The accurate prediction of biological features from genomic data is paramount for precision medicine and sustainable agriculture. For decades, neural network models have been widely popular in fields like computer vision, astrophysics and...
Communications biology
Apr 4, 2022
Bayesian networks (BNs) are disciplined, explainable Artificial Intelligence models that can describe structured joint probability spaces. In the context of understanding complex relations between a number of variables in biological settings, they ca...
IEEE/ACM transactions on computational biology and bioinformatics
Apr 1, 2022
Previous studies have either learned drug's features from their string or numeric representations, which are not natural forms of drugs, or only used genomic data of cell lines for the drug response prediction problem. Here, we proposed a deep learni...
BMC genomics
Mar 31, 2022
BACKGROUND: The recent big data revolution in Genomics, coupled with the emergence of Deep Learning as a set of powerful machine learning methods, has shifted the standard practices of machine learning for Genomics. Even though Deep Learning methods ...