AIMC Topic: HLA-A Antigens

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Snowflake: A deep learning-based human leukocyte antigen matching algorithm considering allele-specific surface accessibility.

Frontiers in immunology Jul 29, 2022
Histocompatibility in solid-organ transplantation has a strong impact on long-term graft survival. Although recent advances in matching of both B-cell epitopes and T-cell epitopes have improved understanding of allorecognition, the immunogenic determ...
Humans Algorithms Deep Learning HLA Antigens Alleles Solvents HLA-A Antigens Epitopes, B-Lymphocyte
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Deep learning pan-specific model for interpretable MHC-I peptide binding prediction with improved attention mechanism.

Proteins Mar 18, 2021
Accurate prediction of peptide binding affinity to the major histocompatibility complex (MHC) proteins has the potential to design better therapeutic vaccines. Previous work has shown that pan-specific prediction algorithms can achieve better predict...
Humans Peptides Deep Learning Protein Binding Databases, Protein Area Under Curve Benchmarking Alleles Datasets as Topic Binding Sites HLA-A Antigens
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Graphical classification of DNA sequences of HLA alleles by deep learning.

Human cell Jan 11, 2018
Alleles of human leukocyte antigen (HLA)-A DNAs are classified and expressed graphically by using artificial intelligence "Deep Learning (Stacked autoencoder)". Nucleotide sequence data corresponding to the length of 822 bp, collected from the Immuno...
Humans Artificial Intelligence Sequence Analysis, DNA Alleles Base Sequence Databases, Nucleic Acid HLA-A Antigens
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ESMpHLA: Evolutionary Scale Model-Based Deep Learning Prediction of HLA Class I Binding Peptides.

HLA May 1, 2025
The recognition of endogenous peptides by HLA class I plays a crucial role in CD8+ T cell immune responses and human adaptive cell immune. Thus, the prediction of HLA class I-peptide binding affinities is always the core issue for the research of imm...
Humans Peptides Deep Learning ROC Curve Protein Binding Computational Biology Alleles Histocompatibility Antigens Class I HLA-A Antigens HLA-B Antigens HLA-C Antigens
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Sequence based human leukocyte antigen gene prediction using informative physicochemical properties.

International journal of data mining and bioinformatics Jan 1, 2015
Prediction of different classes within the human leukocyte antigen (HLA) gene family can provide insight into the human immune system and its response to viral pathogens. Therefore, it is desirable to develop an efficient and easily interpretable met...
Humans Algorithms Support Vector Machine Databases, Protein Structure-Activity Relationship Leukocytes Amino Acid Sequence Data Mining Pattern Recognition, Automated Molecular Sequence Data Sequence Analysis, Protein HLA-A Antigens
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