AIMC Topic: Immunodominant Epitopes

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Deep learning predictions of TCR-epitope interactions reveal epitope-specific chains in dual alpha T cells.

Nature communications Apr 13, 2024
T cells have the ability to eliminate infected and cancer cells and play an essential role in cancer immunotherapy. T cell activation is elicited by the binding of the T cell receptor (TCR) to epitopes displayed on MHC molecules, and the TCR specific...
Humans COVID-19 T-Lymphocytes Deep Learning Epitopes Immunodominant Epitopes
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Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space.

Frontiers in immunology Apr 16, 2019
Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different...
Humans Machine Learning Computer Simulation T-Lymphocytes Epitopes, T-Lymphocyte Receptors, Antigen, T-Cell Computational Biology Datasets as Topic Adaptive Immunity Thermodynamics Major Histocompatibility Complex Antigen Presentation Immunodominant Epitopes
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