AIMC Topic: Machine Learning

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Construction of classification models for pathogenic bacteria based on LIBS combined with different machine learning algorithms.

Applied optics
Bacteria, especially foodborne pathogens, seriously threaten human life and health. Rapid discrimination techniques for foodborne pathogens are still urgently needed. At present, laser-induced breakdown spectroscopy (LIBS), combined with machine lear...

Machine-designed biotherapeutics: opportunities, feasibility and advantages of deep learning in computational antibody discovery.

Briefings in bioinformatics
Antibodies are versatile molecular binders with an established and growing role as therapeutics. Computational approaches to developing and designing these molecules are being increasingly used to complement traditional lab-based processes. Nowadays,...

Mitigating cold-start problems in drug-target affinity prediction with interaction knowledge transferring.

Briefings in bioinformatics
Predicting the drug-target interaction is crucial for drug discovery as well as drug repurposing. Machine learning is commonly used in drug-target affinity (DTA) problem. However, the machine learning model faces the cold-start problem where the mode...

Application of non-negative matrix factorization in oncology: one approach for establishing precision medicine.

Briefings in bioinformatics
The increase in the expectations of artificial intelligence (AI) technology has led to machine learning technology being actively used in the medical field. Non-negative matrix factorization (NMF) is a machine learning technique used for image analys...

Comparative analysis of machine learning algorithms on the microbial strain-specific AMP prediction.

Briefings in bioinformatics
The evolution of drug-resistant pathogenic microbial species is a major global health concern. Naturally occurring, antimicrobial peptides (AMPs) are considered promising candidates to address antibiotic resistance problems. A variety of computationa...

Heterogeneous data integration methods for patient similarity networks.

Briefings in bioinformatics
Patient similarity networks (PSNs), where patients are represented as nodes and their similarities as weighted edges, are being increasingly used in clinical research. These networks provide an insightful summary of the relationships among patients a...

Ab initio machine learning of phase space averages.

The Journal of chemical physics
Equilibrium structures determine material properties and biochemical functions. We here propose to machine learn phase space averages, conventionally obtained by ab initio or force-field-based molecular dynamics (MD) or Monte Carlo (MC) simulations. ...

Automated workflow for computation of redox potentials, acidity constants, and solvation free energies accelerated by machine learning.

The Journal of chemical physics
Fast evolution of modern society stimulates intense development of new materials with novel functionalities in energy and environmental applications. Due to rapid progress of computer science, computational design of materials with target properties ...

Differential Geometry Methods for Constructing Manifold-Targeted Recurrent Neural Networks.

Neural computation
Neural computations can be framed as dynamical processes, whereby the structure of the dynamics within a neural network is a direct reflection of the computations that the network performs. A key step in generating mechanistic interpretations within ...