AIMC Topic: Oxygenases

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A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes.

Chemical research in toxicology Jul 29, 2019
Pediatric patients are at elevated risk of adverse drug reactions, and there is insufficient information on drug safety in children. Complicating risk assessment in children, there are numerous age-dependent changes in the absorption, distribution, m...
Humans Neural Networks, Computer Infant Adolescent Time Factors Child, Preschool Child Liver Neoplasms Principal Component Analysis Cytochrome P-450 Enzyme System Glutathione Transferase Glucuronosyltransferase Oxygenases Carboxylesterase Inactivation, Metabolic Sulfurtransferases
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Machine learning-assisted directed protein evolution with combinatorial libraries.

Proceedings of the National Academy of Sciences of the United States of America Apr 12, 2019
To reduce experimental effort associated with directed protein evolution and to explore the sequence space encoded by mutating multiple positions simultaneously, we incorporate machine learning into the directed evolution workflow. Combinatorial sequ...
Humans Machine Learning Models, Molecular Amino Acid Sequence Protein Conformation Directed Molecular Evolution Small Molecule Libraries Combinatorial Chemistry Techniques Oxygenases Rhodothermus
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