AIMC Topic: Peptide Nucleic Acids

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AI-designed PNA-peptide chimera overcomes suboptimal binding for dual inhibition of viral RdRp.

European journal of medicinal chemistry Nov 16, 2025
The chimera combining the peptide nucleic acids (PNAs) and peptides represent a promising bifunctional strategy by concurrently binding with protein catalytic pocket and its associated RNA template, effectively disrupting protein's function. Conventi...
Humans Artificial Intelligence SARS-CoV-2 Peptides Drug Design Antiviral Agents Protein Binding Peptide Nucleic Acids Thermodynamics RNA-Dependent RNA Polymerase
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Development and application of Peptide Nucleic Acid Fluorescence in situ Hybridization for the specific detection of Listeria monocytogenes.

Food microbiology Dec 15, 2018
Listeria monocytogenes is one of the most important foodborne pathogens due to the high hospitalization and mortality rates associated to an outbreak. Several new molecular methods that accelerate the identification of L. monocytogenes have been deve...
Sensitivity and Specificity Animals Food Contamination Food Microbiology Listeria monocytogenes In Situ Hybridization, Fluorescence Nucleic Acid Probes Peptide Nucleic Acids Reagent Kits, Diagnostic
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